Van der Vieren M, Le Trong H, Wood C L, Moore P F, St John T, Staunton D E, Gallatin W M
ICOS Corporation, Bothell, Washington 98021, USA.
Immunity. 1995 Dec;3(6):683-90. doi: 10.1016/1074-7613(95)90058-6.
The leukocyte-restricted beta 2 (CD18) integrins mediate cell adhesion in a variety of events essential for normal immune function. Despite extensive research in this field, only three members of this integrin subfamily have been described: CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1), and CD11c/CD18 (p150,95). We have identified a cDNA encoding a fourth alpha chain, alpha d, that associates with CD18. The alpha d subunit is more closely related to CD11b and CD11c than to CD11a. This integrin is expressed at moderate levels on myelomonocytic cell lines and subsets of peripheral blood leukocytes, and more strongly on tissue-compartmentalized cells such as foam cells, specialized macrophages found in aortic fatty streaks that may develop into atherosclerotic lesions. The alpha d/CD18 molecule exhibits preferential recognition of ICAM-3 over ICAM-1.
白细胞限制性β2（CD18）整合素在正常免疫功能所必需的各种事件中介导细胞黏附。尽管该领域已有广泛研究，但该整合素亚家族仅描述了三个成员：CD11a/CD18（淋巴细胞功能相关抗原-1）、CD11b/CD18（巨噬细胞-1抗原）和CD11c/CD18（p150,95）。我们已鉴定出一种编码与CD18相关的第四条α链αd的cDNA。αd亚基与CD11b和CD11c的关系比与CD11a的关系更密切。这种整合素在骨髓单核细胞系和外周血白细胞亚群上中等水平表达，而在组织分隔细胞如泡沫细胞（在主动脉脂肪条纹中发现的可能发展为动脉粥样硬化病变的特殊巨噬细胞）上表达更强。αd/CD18分子对细胞间黏附分子-3（ICAM-3）的识别优于对细胞间黏附分子-1（ICAM-1）的识别。
