Demirkiran M, Jankovic J, Dean J M
Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA.
Clin Neuropharmacol. 1996 Apr;19(2):157-64. doi: 10.1097/00002826-199619020-00004.
3,4-Methylenedioxymethamphetamine (MDMA), also known as "ecstasy" is a popular recreational drug with potential for abuse. Although its neurotoxic effects have been established in animal studies, the acute and long-term effects of this serotonergic agent in humans are still unknown. We describe a 19-year-old woman with overlapping symptoms of neuroleptic malignant syndrome and serotonin syndrome after a single exposure to MDMA. We also review 15 other cases reported in the literature to draw attention to the serious neurotoxicity, including fatal outcomes, caused by the use of this increasingly popular, illicit drug.
3,4-亚甲基二氧甲基苯丙胺（MDMA），又称“摇头丸”，是一种常见的具有滥用潜力的消遣性毒品。尽管其神经毒性作用已在动物研究中得到证实，但这种血清素能药物对人类的急性和长期影响仍不明确。我们描述了一名19岁女性，在单次服用MDMA后出现了与抗精神病药物恶性综合征和血清素综合征重叠的症状。我们还回顾了文献中报道的其他15例病例，以引起人们对使用这种日益流行的非法药物所导致的严重神经毒性（包括致命后果）的关注。
