Zarcone R, Bellini P, Cardone G, Vicinanza G, Cardone A
Department of Obstetrics and Gynecology, Second University of Naples.
Clin Exp Obstet Gynecol. 1995;22(4):298-300.
Epidermal growth factor was investigated in normal and malignant tissues in order to detect possible differences in its expression. We used immunohistochemical techniques that employ murine monoclonal antibody 528. Thirty-nine patients (12 with normal endometria and 27 with endometrial adenocarcinomas) were examined. Epidermal growth factor receptor was seen in all normal uteri and in 27 uteri with adenocarcinoma. It was absent in 11 patients with cancer. No correlation was found between the intensity of immunohistochemical staining and histologic grade, depth of myometrial invasion and clinical stage.
为了检测其表达的可能差异，对正常组织和恶性组织中的表皮生长因子进行了研究。我们使用了采用鼠单克隆抗体528的免疫组织化学技术。对39例患者（12例正常子宫内膜患者和27例子宫内膜腺癌患者）进行了检查。在所有正常子宫和27例患有腺癌的子宫中均可见表皮生长因子受体。11例癌症患者中未发现该受体。免疫组织化学染色强度与组织学分级、肌层浸润深度和临床分期之间未发现相关性。
