来自库拉索芦荟的抗炎 C-葡萄糖基色酮。
Antiinflammatory C-glucosyl chromone from Aloe barbadensis.
作者信息
Hutter J A, Salman M, Stavinoha W B, Satsangi N, Williams R F, Streeper R T, Weintraub S T
机构信息
Department of Pharmacology, Research Imaging Center, University of Texas Health Science Center at San Antonio, 78284-7760, USA.
出版信息
J Nat Prod. 1996 May;59(5):541-3. doi: 10.1021/np9601519.
A new antiinflammatory agent identified as 8-[C-beta-D-[2-O-(E)-cinnamoyl]glucopyranosyl]-2- [(R)-2-hydroxypropyl]-7-methoxy-5-methylchromone (1) has been isolated from Aloe barbadensis Miller. At a dose of 200 microg/mouse ear, 1 exhibited topical antiinflammatory activity equivalent to 200 microg/ear of hydrocortisone. There was no reduction in thymus weight caused by treatment with 1 for any of the doses tested, while 200 microg/ear of hydrocortisone resulted in a 50% decrease in thymus weight.
从库拉索芦荟中分离出一种新的抗炎剂，鉴定为8-[C-β-D-[2-O-(E)-肉桂酰基]吡喃葡萄糖基]-2-[(R)-2-羟丙基]-7-甲氧基-5-甲基色酮（1）。在剂量为200μg/小鼠耳时，1表现出与200μg/耳氢化可的松相当的局部抗炎活性。在所测试的任何剂量下，用1处理均未导致胸腺重量减轻，而200μg/耳氢化可的松导致胸腺重量减少50%。
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