肌萎缩侧索硬化症中的镫骨肌反射
Stapedial reflex in amyotrophic lateral sclerosis.
作者信息
Shimizu T, Hayashida T, Hayashi H, Kato S, Tanabe H
机构信息
Department of Neurology, Tokyo Metropolitan Neurological Hospital, Japan.
出版信息
J Neurol Neurosurg Psychiatry. 1996 May;60(5):544-8. doi: 10.1136/jnnp.60.5.544.
OBJECTIVE
To examine mechanisms controlling the stapedial reflex in patients with amyotrophic sclerosis (ALS).
METHODS
The stapedial reflex was examined using impedance audiometry in 38 patients with sporadic ALS and in 25 age matched controls.
RESULTS
All patients showed normal reflex decay test results. There were no significant differences between patients with ALS and control subjects in reflex threshold, latency, amplitude, or contraction time (C50). Although each reflex variable in the patients with classic or progressive muscular atrophy types of ALS showed no significant difference from that in control subjects, the patients with bulbar type ALS showed significantly longer latency, C50, and retraction time (D50), and significantly lower amplitude than control subjects. Three types of abnormal reflex waveforms (polyphasic, abnormally delayed retraction, and abnormally early retraction) were noted in six patients.
CONCLUSION
The subclinical involvement of the stapedius motor neurons or of the supranuclear stapedius motor system might be responsible for the abnormalities of the stapedial reflex in ALS.
目的
研究肌萎缩侧索硬化症（ALS）患者镫骨肌反射的控制机制。
方法
采用声阻抗测听法对38例散发性ALS患者和25例年龄匹配的对照者进行镫骨肌反射检查。
结果
所有患者的反射衰减试验结果均正常。ALS患者与对照者在反射阈值、潜伏期、振幅或收缩时间（C50）方面无显著差异。尽管经典型或进行性肌萎缩型ALS患者的各项反射变量与对照者相比无显著差异，但延髓型ALS患者的潜伏期、C50和回缩时间（D50）显著延长，振幅显著低于对照者。6例患者出现了三种异常反射波形（多相波、异常延迟回缩和异常早期回缩）。
结论
镫骨肌运动神经元或核上镫骨肌运动系统的亚临床受累可能是ALS患者镫骨肌反射异常的原因。
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