Cirisano F D, Lee S, Greenspoon J S
Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
J Reprod Med. 1996 Mar;41(3):191-4.
During the puerperium, heparin levels, rather than the adjusted partial thromboplastin time test, can be used to identify heparin resistance and guide heparin therapy.
A patient receiving heparin for deep venous thrombosis had artifactual resistance to heparin, with a short adjusted partial thromboplastin time due to elevation of factor VIII. Heparin assay revealed a heparin level above the therapeutic range.
Direct measurement of heparin concentration and factor VIII activity should be performed when heparin resistance is suspected.
在产褥期，可使用肝素水平而非活化部分凝血活酶时间试验来识别肝素抵抗并指导肝素治疗。
一名因深静脉血栓接受肝素治疗的患者出现了肝素假性抵抗，由于因子VIII升高，活化部分凝血活酶时间缩短。肝素测定显示肝素水平高于治疗范围。
怀疑存在肝素抵抗时，应直接测定肝素浓度和因子VIII活性。
