Simonowitz D, Block G E, Riddell R H, Kraft S C, Kirsner J B
Surgery. 1977 Aug;82(2):211-8.
Recent reports have suggested a transmissible factor in the etiology of Crohn's disease, which had yet to be confirmed. The specificity of the transmission was tested with a disease control of ulcerative colitis as well as normal bowel. Twenty New Zealand White rabbits received inoculum of tissue homogenates from the terminal ileum of normal, ulcerative colitic, and Crohn's disease patients. This inoculum was injected into the wall of the ascending colon and the animals were examined after one year. Changes were noted consistently only in those animals receiving the Crohn's disease inoculum. These changes consisted of thickened bowel wall with increased mucosal folds, thickened mesenteric fat with some creeping, irregular areas of thin colonic mucosa, and hyperplastic mesenteric lymph nodes. The terminal ileum distant from the inoculum site was smooth with atrophic changes only in the Crohn's inoculated group of animals. These animals also had discrete collections of macrophages in colon or sacculus, mucosal and submucosal edema, and chronic inflammation of the colon. However, the characteristic features of Crohn's disease were not reproduced.
最近的报告提示在克罗恩病的病因中存在一种可传播因素，但尚未得到证实。采用溃疡性结肠炎疾病对照以及正常肠组织来测试这种传播的特异性。20只新西兰白兔接受了来自正常、溃疡性结肠炎和克罗恩病患者回肠末端的组织匀浆接种物。将该接种物注入升结肠壁，一年后对动物进行检查。仅在接受克罗恩病接种物的动物中持续观察到变化。这些变化包括肠壁增厚伴黏膜皱襞增多、肠系膜脂肪增厚伴一些蔓延、结肠黏膜变薄的不规则区域以及肠系膜淋巴结增生。远离接种部位的回肠末端在仅接受克罗恩病接种的动物组中是光滑的，但有萎缩性改变。这些动物在结肠或囊袋中也有离散的巨噬细胞聚集、黏膜和黏膜下水肿以及结肠慢性炎症。然而，并未重现克罗恩病的特征性表现。
