Solhaug J H, Bjerkeset T, Halvorsen J F
Surgery. 1977 Aug;82(2):248-53.
In the present series, highly selective vagotomy (HSV) was used in the treatment of duodenal ulcer and the patients were followed up 1 to 3 years after operation. Three months after operation, 57% of the patients had positive insulin tests (early and late positive). Ulcer recurrence rate was approximately 6.5%, whereas 18% of the results were judged to be therapeutic failures. The operations were done during the period of introduction of the method in a general surgical department of a teaching hospital, when the enthusiasm was great and the experience of the individual surgeon with HSV was small. The moderately poor results in this series are thought to be due to too many surgeons operating on a rather limited number of patients. Unrelated to this situation, a statistically significant increase in the frequency of positive insulin tests during the observation period was found, giving an incidence of 80% positive tests 2 years after the operation.
在本系列研究中，采用高选择性迷走神经切断术（HSV）治疗十二指肠溃疡，并对患者术后1至3年进行随访。术后三个月，57%的患者胰岛素试验呈阳性（早期和晚期阳性）。溃疡复发率约为6.5%，而18%的结果被判定为治疗失败。这些手术是在一所教学医院的普通外科引入该方法期间进行的，当时热情高涨，但个别外科医生对HSV的经验较少。本系列研究结果中等偏差被认为是由于过多的外科医生对相对有限数量的患者进行手术所致。与这种情况无关的是，在观察期内发现胰岛素试验阳性频率有统计学意义的增加，术后两年阳性试验发生率达80%。
