Spencer G S, Decuypere E, Buyse J, Zeman M
Laboratory for Physiology and Immunology of Domestic Animals, Catholic University of Leuven, Heverlee, Belgium.
Poult Sci. 1996 Mar;75(3):388-92. doi: 10.3382/ps.0750388.
Osmotic minipumps containing either saline or recombinant human insulin-like growth factor-II (IGF-II) were implanted into 4-wk-old female broiler chickens such that the treated chickens received 0.5 mg IGF-II/kg body weight per d. At the end of the trial, no differences in body weight gain or bone length were detected between the treated and control groups. Similarly, there were no differences between the two treatments with respect to heart, spleen, liver, or bursa of Fabricius weight. The relative weight of the abdominal fat pads was greater (P < 0.05) in the birds treated with IGF-II than in the controls, whereas the weight of breast muscle was reduced (P = 0.06) in the birds treated with IGF-II. There was no effect of IGF-II treatment on feed intake or feed conversion efficiency. Plasma growth hormone (GH) levels were acutely depressed by 15 min after IGF-II administration; and also after 2 wk of IGF-II treatment. Plasma triiodothyronine (T3) concentrations were significantly depressed by IGF-II treatment. These results suggest that IGF-II may not stimulate growth in chickens, but can act as a nutrient partitioning agent, either directly or indirectly through altering plasma GH or T3 concentrations.
将装有生理盐水或重组人胰岛素样生长因子-II（IGF-II）的渗透微型泵植入4周龄雌性肉鸡体内，使接受治疗的鸡每天每千克体重摄入0.5毫克IGF-II。在试验结束时，治疗组和对照组之间在体重增加或骨骼长度方面未检测到差异。同样，在心脏、脾脏、肝脏或法氏囊重量方面，两种处理之间也没有差异。与对照组相比，接受IGF-II治疗的鸡腹部脂肪垫的相对重量更大（P<0.05），而接受IGF-II治疗的鸡胸肌重量减少（P = 0.06）。IGF-II处理对采食量或饲料转化效率没有影响。给予IGF-II后15分钟，血浆生长激素（GH）水平急剧下降；在IGF-II治疗2周后也是如此。IGF-II处理显著降低了血浆三碘甲状腺原氨酸（T3）浓度。这些结果表明，IGF-II可能不会刺激鸡的生长，但可以直接或通过改变血浆GH或T3浓度间接作为一种营养分配剂。
