Rose D P
Division of Nutrition and Endocrinology, American Health Foundation, Valhalla, New York 10595, USA.
Prev Med. 1996 Jan-Feb;25(1):34-7. doi: 10.1006/pmed.1996.0012.
Mechanistic studies are an essential component of dietary cancer prevention trials. In breast and prostate cancer, a low-fat diet with a reduction in omega-6 fatty acid may prove effective, not only because of related decreases in sex steroid hormones, but as a result of altered eicosanoid biosynthesis. An optimal approach to primary and secondary prevention is likely to be a dietary change combined with one or more pharmacologically based chemopreventive agents. Patients with in situ carcinoma of the breast or prostate are candidates for dietary intervention as a means of secondary prevention.
机制研究是饮食防癌试验的重要组成部分。在乳腺癌和前列腺癌中，减少ω-6脂肪酸的低脂饮食可能被证明是有效的，这不仅是因为性类固醇激素相应减少，还因为类二十烷酸生物合成的改变。一级和二级预防的最佳方法可能是饮食改变与一种或多种基于药理学的化学预防剂相结合。乳腺或前列腺原位癌患者可作为二级预防手段接受饮食干预。
