Carley D W, Trbovic S, Radulovacki M
Department of Pharmacology, College of Medicine, University of Illinois at Chicago 60612, USA.
Physiol Behav. 1996 Apr-May;59(4-5):827-31. doi: 10.1016/0031-9384(95)02205-8.
The effects of hypertension and REM sleep deprivation on spontaneous and postsigh apneas have been studied in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats by simultaneously monitoring their respiration and sleep by the EEG. The amount of REM and non-REM sleep in SHR rats was identical to WKY rats under control as well as REM sleep-deprived recording conditions. Hypertension was associated with an increase in postsigh apneas, as was evident by the increased postsigh apnea index in non-REM and total sleep in SHR rats when compared to normotensive WKY rats. In contrast, REM sleep deprivation suppressed the postsigh apnea expression both in non-REM and total sleep in SHR rats. The incidence of spontaneous apneas was increased by a combination of hypertension and REM sleep deprivation, as was shown in REM-deprived SHR rats, while each of these conditions alone had no effect on spontaneous apneas. These results suggest a role for hypertension in the postsigh apnea genesis and the existence of partially distinct mechanisms for the two types of apneas.
通过脑电图同时监测血压正常的Wistar-Kyoto（WKY）大鼠和自发性高血压（SHR）大鼠的呼吸和睡眠，研究了高血压和快速眼动睡眠剥夺对自发性叹息后呼吸暂停和叹息后呼吸暂停的影响。在对照以及快速眼动睡眠剥夺记录条件下，SHR大鼠的快速眼动睡眠和非快速眼动睡眠量与WKY大鼠相同。高血压与叹息后呼吸暂停增加有关，与血压正常的WKY大鼠相比，SHR大鼠非快速眼动睡眠和总睡眠中叹息后呼吸暂停指数增加就证明了这一点。相比之下，快速眼动睡眠剥夺抑制了SHR大鼠非快速眼动睡眠和总睡眠中的叹息后呼吸暂停表现。如在快速眼动睡眠剥夺的SHR大鼠中所示，高血压和快速眼动睡眠剥夺共同作用会增加自发性呼吸暂停的发生率，而单独的每种情况对自发性呼吸暂停均无影响。这些结果表明高血压在叹息后呼吸暂停发生中起作用，并且两种类型的呼吸暂停存在部分不同的机制。
