Posener J A, Schildkraut J J, Samson J A, Schatzberg A F
Massachusetts Mental Health Center, Boston 02115, USA.
Psychoneuroendocrinology. 1996 Jan;21(1):33-8. doi: 10.1016/0306-4530(95)00033-x.
We investigated the relationship between plasma levels of cortisol, the dopamine metabolite homovanillic acid (HVA) and norepinephrine in healthy human subjects. Plasma cortisol and HVA levels were measured at 0800h, and in an integrated sampling procedure involving samples every 15 min between 1300 and 1600h. Plasma norepinephrine was measured at 0800 and 1300h. Cortisol, HVA and norepinephrine indices did not show significant correlations with each other. Both cortisol and HVA showed significant decreases over time. Longitudinal Random Effects (LRE) models were used to test whether individual cortisol and HVA curves over time were correlated; significant correlations were not found with this procedure. While significant correlations between cortisol and catecholamine indices have been reported in depressed patients, our results do not suggest such correlations in healthy subjects.
我们研究了健康人体受试者血浆中皮质醇、多巴胺代谢产物高香草酸（HVA）和去甲肾上腺素水平之间的关系。在上午8点测量血浆皮质醇和HVA水平，并在1300至1600小时之间采用每15分钟采集一次样本的综合采样程序。在上午8点和13点测量血浆去甲肾上腺素。皮质醇、HVA和去甲肾上腺素指标之间未显示出显著相关性。皮质醇和HVA均随时间显著下降。采用纵向随机效应（LRE）模型来检验个体皮质醇和HVA随时间变化的曲线是否相关；通过该程序未发现显著相关性。虽然在抑郁症患者中已报道皮质醇与儿茶酚胺指标之间存在显著相关性，但我们的结果并未表明健康受试者中存在此类相关性。
