Yue B Y
University of Illinois at Chicago, Department of Ophthalmology and Visual Sciences, Lions of Illinois Eye Research Institute, Chicago, USA.
Surv Ophthalmol. 1996 Mar-Apr;40(5):379-90. doi: 10.1016/s0039-6257(96)80066-x.
The extracellular matrix (ECM) in the trabecular meshwork is is believed to be essential for maintenance of the normal outflow system. Excessive, abnormal accumulations of ECM materials have been noted in the trabecular meshwork of eyes obtained from patients with primary open angle glaucoma. This review summarizes the current knowledge regarding the composition of this matrix and the receptors for ECM proteins in the trabecular meshwork. Modulations of the ECM elements by constituents in the aqueous humor after phagocytic challenges and by glucocorticoids are also described. The ECM is known to regulate cell differentiation and cell behavior in a number of systems. It will thus be of particular interest to establish the relationship between the modulated ECM and the functional status of trabecular meshwork cells and to examine the possible relevance of such modulation to outflow resistance.
小梁网中的细胞外基质（ECM）被认为对维持正常的房水流出系统至关重要。在原发性开角型青光眼患者的眼中，已观察到小梁网中存在过量、异常积聚的ECM物质。本综述总结了关于该基质组成以及小梁网中ECM蛋白受体的当前知识。还描述了吞噬刺激后房水中成分以及糖皮质激素对ECM成分的调节作用。已知ECM在许多系统中调节细胞分化和细胞行为。因此，确定调节后的ECM与小梁网细胞功能状态之间的关系，并研究这种调节与流出阻力的可能相关性将特别有趣。
