Golov K G, Varshavskiĭ V A, Okunev D Iu, Neverov N I, Shestakova M V, Proskurneva F P
Ter Arkh. 1995;67(10):80-1.
The activity of gamma-glutamyl transferase (GGT), alkaline phosphatase (AP), lactate dehydrogenase (LDG), N-acetyl-beta-D-glucosaminidase (NAG) was assessed in 53 patients with psoriasis (PS), 24 PS patients with affected kidneys, 50 patients with type 1 diabetes mellitus(DM). Enhanced activity of the enzymes occurred not only in nephropathy patients but also in those without proteinuria. AP and NAG were more active in PS, while LDG and NAG in DM. Both in PS and DM, NAG activity rose 3-4-fold compared to control. A direct correlation was found between enzymuria and uremia, glycemia (in hyperglycemia only) and cholesterolemia. An inverse relationship existed between enzymuria and uricosuria. The above changes in enzymic activity are attributed to impairment of tubules of the kidney induced by PS and DM. Diagnostic significance of enzymuria as a marker of early tubular involvement is confirmed by investigations of renal biopsies.
对53例银屑病（PS）患者、24例患有肾脏病变的PS患者以及50例1型糖尿病（DM）患者的γ-谷氨酰转移酶（GGT）、碱性磷酸酶（AP）、乳酸脱氢酶（LDG）、N-乙酰-β-D-氨基葡萄糖苷酶（NAG）活性进行了评估。酶活性增强不仅出现在肾病患者中，也出现在无蛋白尿的患者中。AP和NAG在PS患者中活性更高，而LDG和NAG在DM患者中活性更高。在PS和DM患者中，NAG活性相较于对照组均升高了3至4倍。发现酶尿症与尿毒症、血糖（仅在高血糖时）及胆固醇血症之间存在直接关联。酶尿症与尿酸尿症之间存在负相关关系。上述酶活性变化归因于PS和DM所致的肾小管损伤。通过肾活检研究证实了酶尿症作为早期肾小管受累标志物的诊断意义。
