Hughes M F, Hall L L
ManTech Environmental Technology, Inc., Research Triangle Park, NC 27709, USA.
Xenobiotica. 1995 Aug;25(8):873-83. doi: 10.3109/00498259509061900.
The absorption and elimination of [14C]-phenol (63.5 nmol) after oral, dermal, intratracheal, or intravenous administration in rat was rapid and extensive. Urinary elimination of radioactivity predominated, with a range of 75-95% of the dose detected in urine by 72 h post-exposure. Washing the dermal site 72 h post-exposure removed 14% of the dose. Two per cent of the dose was detected in the skin. The urinary metabolites at 4 and 8 h after administration by the four routes included phenyl sulphate and lower amounts of phenyl glucuronide. Phenol was poorly retained in the body after administration by the four routes. Phenol remaining in the body was widely distributed, with accumulation primarily in the liver, lung, and kidney.
大鼠经口、经皮、气管内或静脉注射给予[14C] - 苯酚（63.5纳摩尔）后，其吸收和消除迅速且广泛。放射性物质主要通过尿液消除，在暴露后72小时，尿液中检测到的剂量占比为75 - 95%。暴露后72小时清洗皮肤部位可去除14%的剂量。在皮肤中检测到2%的剂量。经四种途径给药后4小时和8小时的尿液代谢产物包括硫酸苯酯和少量的苯葡糖醛酸。经四种途径给药后，苯酚在体内的潴留较差。体内残留的苯酚分布广泛，主要蓄积在肝脏、肺和肾脏。
