Shmagel' K V, Kaminina I V, Markova A M
Akush Ginekol (Mosk). 1995(6):22-5.
The concentrations of trophoblastic b1-globulin (TBG) were measured in the blood sera of 205 healthy women at pregnancy terms of 4 to 40 weeks and in 101 ones with threatened abortions at terms of 5 to 24 weeks. Normal TBG values for each gestation week were derived by regression analysis. TBG levels in women with threatened abortion were compared with the normal values for certain gestation terms and expressed in relative values (% of the normal value). The efficacy of treatment of threatened miscarriage was assessed on the basis of the relative values in 60 women. The results indicate that TBG may be increased or decreased in threatened abortion. Effective therapy leads to normalization of this parameter. A drastic (by several times) drop of TBG level in comparison with the concentration normal for the corresponding pregnancy term sharply increases the risk of an unfavorable outcome.
在205名怀孕4至40周的健康女性以及101名怀孕5至24周有先兆流产迹象的女性的血清中，测定了滋养层β1-球蛋白（TBG）的浓度。通过回归分析得出了每个孕周的正常TBG值。将有先兆流产迹象女性的TBG水平与特定孕周的正常值进行比较，并以相对值（正常值的百分比）表示。根据60名女性的相对值评估了先兆流产治疗的效果。结果表明，先兆流产时TBG可能升高或降低。有效的治疗可使该参数恢复正常。与相应孕周的正常浓度相比，TBG水平急剧下降（数倍）会显著增加不良结局的风险。
