Gan Y Y, Fones-Tan A, Chan S H
School of Science, NIE, Nanyang Technological University, Singapore.
Ann Acad Med Singap. 1996 Jan;25(1):71-4.
The various antigen complexes of the Epstein-Barr virus (EBV) are broadly classified as the viral capsid antigen (VCA), diffuse early antigen (EA-D), restricted early antigen (EA-R), membrane antigen (MA) and the Epstein-Barr nuclear antigen (EBNA). The different EBV-related diseases may be differentiated according to the reactivity of these different classes of antibodies towards the various classes of antigen complexes. However, with the recent development of molecular biology, it is now known that the individual polypeptides of the different EBV antigen complexes can be used as serological markers for the detection of nasopharyngeal carcinoma (NPC). Among the useful serological markers which have been used in enzyme-linked immunosorbent assay (ELISA) for the detection of NPC are the gp125 from the VCA complex (IgA), pp58 from the EA-D complex (IgG), ribonucleotide reductase (IgG and IgA), DNase (IgA) and thymidine kinase (IgA) from the EA-R complex, gp 250/200 from the MA complex (IgA) and the ZEBRA antigen (IgA).
爱泼斯坦-巴尔病毒（EBV）的各种抗原复合物大致分为病毒衣壳抗原（VCA）、弥散早期抗原（EA-D）、局限早期抗原（EA-R）、膜抗原（MA）和爱泼斯坦-巴尔核抗原（EBNA）。不同的EBV相关疾病可根据这些不同类别的抗体对各类抗原复合物的反应性来区分。然而，随着分子生物学的最新发展，现已知道不同EBV抗原复合物的各个多肽可作为检测鼻咽癌（NPC）的血清学标志物。在用于酶联免疫吸附测定（ELISA）检测NPC的有用血清学标志物中，有来自VCA复合物的gp125（IgA）、来自EA-D复合物的pp58（IgG）、核糖核苷酸还原酶（IgG和IgA）、来自EA-R复合物的脱氧核糖核酸酶（IgA）和胸苷激酶（IgA）、来自MA复合物的gp 250/200（IgA）以及ZEBRA抗原（IgA）。
