Laviano A, Meguid M M, Gleason J R, Yang Z J, Renvyle T
Department of Surgery, University Hospital, State University of New York Health Science Center, Syracuse 13210, USA.
Am J Physiol. 1996 Feb;270(2 Pt 2):R413-9. doi: 10.1152/ajpregu.1996.270.2.R413.
We studied the effect of gender on food intake, meal number, and meal size in eight 10-wk-old female and seven age-matched male Fischer 344 rats for 44 consecutive days. Although food intake (g/100 g body wt) was similar in males and females (5.42 +/- 0.10 vs. 5.13 +/- 0.13 g food.day-1.100 g body wt-1, respectively; not significant), weight gain in males was approximately seven times greater than in female rats (1.49 +/- 0.07 vs. 0.21 +/- 0.03 g/day, respectively; P < 0.001). During this time, males had a relatively constant food intake. They increased their meal size but decreased their meal number. In female rats, food intake was relatively stable for the duration of the study, despite cyclically and reciprocally recurring changes in meal number and meal size, which are synchronized with the estrous cycle. Data confirm that net food intake is a dynamic process and suggest that, in the rat, the homeostasis of food intake in response to external as well as internal stimuli is maintained via the modulation of meal number and size.
我们对8只10周龄的雌性和7只年龄匹配的雄性Fischer 344大鼠连续44天研究了性别对食物摄入量、进餐次数和进餐量的影响。尽管雄性和雌性的食物摄入量（克/100克体重）相似（分别为5.42±0.10与5.13±0.13克食物·天⁻¹·100克体重⁻¹；无显著差异），但雄性大鼠的体重增加量约为雌性大鼠的7倍（分别为1.49±0.07与0.21±0.03克/天；P<0.001）。在此期间，雄性大鼠的食物摄入量相对恒定。它们增加了进餐量但减少了进餐次数。在雌性大鼠中，尽管进餐次数和进餐量呈周期性和相互交替的变化且与发情周期同步，但在整个研究期间食物摄入量相对稳定。数据证实净食物摄入是一个动态过程，并表明在大鼠中，通过调节进餐次数和进餐量来维持对外部和内部刺激作出反应的食物摄入稳态。
