Bláha V, Yang Z J, Meguid M, Chai J K, Zadák Z
Department of Metabolic Care and Gerontology, Charles University, Faculty of Medicine and Teaching Hospital, Hradec Králové, Czech Republic.
Acta Medica (Hradec Kralove). 1998;41(4):167-73.
The appetite suppressing effect of tobacco products, via the main pharmacological agent nicotine, is a major reason for its usage both by woman and man. Food intake (FI) could be changed by altering either meal size (MZ) or meal number (MN), which are regulated dependently in a reciprocal manner. The present study investigated the effect of systemic nicotine administration on the rat feeding pattern. Because of gender differences in the effects of nicotine, both male and female rats were studied. Alzet mini-osmotic pumps (Model 2001) and the automated rat eatometer were used to evaluate the feeding pattern of male and female Fischer 344 rats during seven days of systemic nicotine infusion (6 mg/kg b.w. s.c.). The main findings are: 1) systemic nicotine infusion decreased food intake in both sexes; 2) the decreased food intake was due to significantly reduced meal sizes while meal numbers were not altered significantly in either males or females; 3) the cyclical pattern of vaginal smears, food intake, meal number and meal size of female rats was not affected by nicotine administration. We conclude that the feeding suppressive effect of nicotine, which is due to reduced meal sizes and thus satiation, is not sex-hormones related.
烟草制品通过其主要药理成分尼古丁产生的食欲抑制作用，是男性和女性使用烟草的主要原因之一。食物摄入量（FI）可以通过改变餐量（MZ）或进餐次数（MN）来改变，二者以相互依赖的方式相互调节。本研究调查了全身给予尼古丁对大鼠进食模式的影响。由于尼古丁作用存在性别差异，因此对雄性和雌性大鼠均进行了研究。使用Alzet微型渗透泵（型号2001）和自动大鼠进食量记录器来评估雄性和雌性Fischer 344大鼠在全身输注尼古丁（6 mg/kg体重，皮下注射）7天期间的进食模式。主要发现如下：1）全身输注尼古丁使两性的食物摄入量均减少；2）食物摄入量减少是由于餐量显著减少，而雄性和雌性的进餐次数均未显著改变；3）尼古丁给药未影响雌性大鼠阴道涂片、食物摄入量、进餐次数和餐量的周期性模式。我们得出结论，尼古丁的进食抑制作用是由于餐量减少从而产生饱腹感，与性激素无关。
