Pinto A V, Pinto M D, Gilbert B, Pellegrino J, Mello R T
Trans R Soc Trop Med Hyg. 1977;71(2):133-5. doi: 10.1016/0035-9203(77)90078-5.
Skin penetration by Schistosoma mansoni cercariae may be blocked by 1,4-and 1,2-naphthoquinones applied topically. Of 23 naphthoquinone derivatives synthesized, 15 afforded almost complete protection when applied in solution to the tails of mice 24 hours before exposure to cercariae. On the basis of present evidence the 5-carbon atom side chain present in naturally occurring lapachol seems to be important for activity, and this is in accord with the previous observation that effective protective agents are liposoluble. Topically applied cercarial penetration inhibitors are presently the only prophylactic agents available for use in the field.
曼氏血吸虫尾蚴对皮肤的穿透可被局部应用的1,4 - 和1,2 - 萘醌所阻断。在合成的23种萘醌衍生物中，有15种在给小鼠尾部分别涂抹溶液24小时后再暴露于尾蚴时，几乎能提供完全的保护。根据现有证据，天然存在的拉帕醇中存在的5 - 碳原子侧链似乎对活性很重要，这与之前观察到的有效保护剂为脂溶性的观点一致。局部应用的尾蚴穿透抑制剂是目前可在现场使用的唯一预防剂。
