Ling P R, Schwartz J H, Jeevanandam M, Gauldie J, Bistrian B R
Laboratory of Nutrition/Infection, New England Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA.
Am J Physiol. 1996 Feb;270(2 Pt 1):E305-12. doi: 10.1152/ajpendo.1996.270.2.E305.
The effects of recombinant interleukin-1 (IL-1), given as a continuous infusion for 6 days, on host responses were determined in rats. The development of fever, change in food intake and body weight, and key components of the acute-phase response in energy and protein metabolism were assessed. The effects of IL-1 were compared with those observed in a matched pair-fed group (semistarved), to distinguish the contribution from anorexia, and in a group that received IL-1 for 4 h acutely. IL-1 significantly increased core temperature, plasma levels of IL-6, and acute-phase protein production and decreased food intake and the circulating zinc level. The catabolic effects of IL-1 on nitrogen loss and muscle protein breakdown were independent of, and additive to those from malnutrition. The changes in energy expenditure, cumulative urinary nitrogen, and hydroxyproline excretion in the chronic IL-1 group were increased over semistarved animals. Finally, changes in muscle protein kinetics were only seen with chronic IL-1 infusion, and the changes in acute-phase protein were greater.
通过对大鼠持续输注重组白细胞介素-1（IL-1）6天，测定其对宿主反应的影响。评估了发热的发展、食物摄入量和体重的变化，以及能量和蛋白质代谢中急性期反应的关键组成部分。将IL-1的作用与在配对的半饥饿喂养组中观察到的作用进行比较，以区分厌食症的影响，并与急性接受IL-1 4小时的组进行比较。IL-1显著升高了核心体温、IL-6的血浆水平以及急性期蛋白的产生，并降低了食物摄入量和循环锌水平。IL-1对氮损失和肌肉蛋白质分解的分解代谢作用与营养不良的作用无关且具有叠加性。慢性IL-1组的能量消耗、累积尿氮和羟脯氨酸排泄的变化比半饥饿动物增加。最后，仅在慢性IL-1输注时观察到肌肉蛋白质动力学的变化，且急性期蛋白的变化更大。
