NLRP3 炎性小体将炎症与代谢性疾病联系起来。
NLRP3 inflammasomes link inflammation and metabolic disease.
机构信息
Institute of Innate Immunity, University Hospitals, Biomedical Centre, University of Bonn, Germany.
出版信息
Trends Immunol. 2011 Aug;32(8):373-9. doi: 10.1016/j.it.2011.05.004. Epub 2011 Jul 4.
Abstract
A strong link between inflammation and metabolism is becoming increasingly evident. A number of recent landmark studies have implicated the activation of the NLRP3 inflammasome, an interleukin-1β family cytokine-activating protein complex, in a variety of metabolic diseases including obesity, atherosclerosis and type 2 diabetes. Here, we review these new developments and discuss their implications for a better understanding of inflammation in metabolic disease, and the prospects of targeting the NLRP3 inflammasome for therapeutic intervention.
摘要
炎症和代谢之间的紧密联系正变得越来越明显。一些最近的重要研究表明，NLRP3 炎性小体（一种白细胞介素-1β家族细胞因子激活蛋白复合物）的激活与多种代谢疾病有关，包括肥胖、动脉粥样硬化和 2 型糖尿病。在这里，我们回顾这些新的发展，并讨论它们对更好地理解代谢性疾病中的炎症以及针对 NLRP3 炎性小体进行治疗干预的前景的影响。
相似文献
1
NLRP3 inflammasomes link inflammation and metabolic disease.NLRP3 炎性小体将炎症与代谢性疾病联系起来。
Trends Immunol. 2011 Aug;32(8):373-9. doi: 10.1016/j.it.2011.05.004. Epub 2011 Jul 4.
2
Sensing damage by the NLRP3 inflammasome.感知 NLRP3 炎性体的损伤。
Immunol Rev. 2011 Sep;243(1):152-62. doi: 10.1111/j.1600-065X.2011.01043.x.
3
A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?NLRP3 炎性体在代谢性疾病中的作用——难道沃伯格错过了炎症？
Nat Immunol. 2012 Mar 19;13(4):352-7. doi: 10.1038/ni.2228.
4
Activation and regulation of the inflammasomes.炎症小体的激活与调控。
Nat Rev Immunol. 2013 Jun;13(6):397-411. doi: 10.1038/nri3452.
5
NLRP3 at the interface of metabolism and inflammation.处于代谢与炎症交界的NLRP3
Immunol Rev. 2015 May;265(1):53-62. doi: 10.1111/imr.12285.
6
Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1β release.前沿：NLRP3 炎性小体将补体介导的炎症与 IL-1β 释放联系起来。
J Immunol. 2013 Aug 1;191(3):1006-10. doi: 10.4049/jimmunol.1300489. Epub 2013 Jul 1.
7
NLRP3 sparks the Greek fire in the war against lipid-related diseases.NLRP3 点燃脂质相关疾病战争中的希腊之火。
Obes Rev. 2020 Sep;21(9):e13045. doi: 10.1111/obr.13045. Epub 2020 May 10.
8
Inflammasome Priming in Sterile Inflammatory Disease.免疫激活物预刺激在非感染性炎症性疾病中的作用。
Trends Mol Med. 2017 Feb;23(2):165-180. doi: 10.1016/j.molmed.2016.12.007. Epub 2017 Jan 18.
9
Histones trigger sterile inflammation by activating the NLRP3 inflammasome.组蛋白通过激活 NLRP3 炎性小体引发无菌性炎症。
Eur J Immunol. 2013 Dec;43(12):3336-42. doi: 10.1002/eji.201243224. Epub 2013 Sep 6.
10
Light induces NLRP3 inflammasome activation in retinal pigment epithelial cells via lipofuscin-mediated photooxidative damage.光通过脂褐素介导的光氧化损伤诱导视网膜色素上皮细胞中NLRP3炎性小体激活。
J Mol Med (Berl). 2015 Aug;93(8):905-16. doi: 10.1007/s00109-015-1275-1. Epub 2015 Mar 18.
引用本文的文献
1
Role of the NLRP3 inflammasome in diabetes and its complications (Review).NLRP3炎性小体在糖尿病及其并发症中的作用（综述）
Mol Med Rep. 2025 Nov;32(5). doi: 10.3892/mmr.2025.13657. Epub 2025 Aug 24.
2
Association of Genetic, Environmental, and Nutritional Factors With Metabolic Phenotypes of Obesity: A Scoping Review.遗传、环境和营养因素与肥胖代谢表型的关联：一项范围综述
J Obes. 2025 Jul 2;2025:8472196. doi: 10.1155/jobe/8472196. eCollection 2025.
3
Interleukin-1 Signaling on Vascular Smooth Muscle Cells Accelerates Atherosclerosis in a Murine Model of Kawasaki Disease.白细胞介素-1在血管平滑肌细胞上的信号传导在川崎病小鼠模型中加速动脉粥样硬化。
J Am Heart Assoc. 2025 Jun 3;14(11):e040687. doi: 10.1161/JAHA.124.040687. Epub 2025 May 26.
4
The Role of NLRP3 Inflammasome in Oral Squamous Cell Carcinoma.NLRP3炎性小体在口腔鳞状细胞癌中的作用
J Inflamm Res. 2025 Apr 25;18:5601-5609. doi: 10.2147/JIR.S512770. eCollection 2025.
5
Expression of innate immunity genes in human hematopoietic stem/progenitor cells - single cell RNA-seq analysis.人类造血干/祖细胞中固有免疫基因的表达——单细胞RNA测序分析
Front Immunol. 2025 Apr 8;16:1515856. doi: 10.3389/fimmu.2025.1515856. eCollection 2025.
6
Targeting Cytokine Dysregulation in Psoriasis: The Role of Dietary Interventions in Modulating the Immune Response.针对银屑病中的细胞因子失调：饮食干预在调节免疫反应中的作用。
Int J Mol Sci. 2025 Mar 22;26(7):2895. doi: 10.3390/ijms26072895.
7
Berberine Ursodeoxycholate for the Treatment of Type 2 Diabetes: A Randomized Clinical Trial.小檗碱熊去氧胆酸治疗2型糖尿病：一项随机临床试验
JAMA Netw Open. 2025 Mar 3;8(3):e2462185. doi: 10.1001/jamanetworkopen.2024.62185.
8
Acid Sphingomyelinase and Ceramide Signaling Pathway Mediates Nicotine-Induced NLRP3 Inflammasome Activation and Podocyte Injury.酸性鞘磷脂酶和神经酰胺信号通路介导尼古丁诱导的NLRP3炎性小体激活和足细胞损伤。
Biomedicines. 2025 Feb 9;13(2):416. doi: 10.3390/biomedicines13020416.
9
Empagliflozin in diabetic cardiomyopathy: elucidating mechanisms, therapeutic potentials, and future directions.恩格列净在糖尿病性心肌病中的作用：阐明机制、治疗潜力及未来方向
Mol Biol Rep. 2025 Jan 24;52(1):158. doi: 10.1007/s11033-025-10260-5.
10
Gut bacterium Intestinimonas butyriciproducens improves host metabolic health: evidence from cohort and animal intervention studies.肠道细菌丁酸生产肠单胞菌改善宿主代谢健康：队列研究和动物干预研究的证据
Microbiome. 2025 Jan 20;13(1):15. doi: 10.1186/s40168-024-02002-9.
本文引用的文献
1
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling.脂肪酸诱导的 NLRP3-ASC 炎性体激活干扰胰岛素信号转导。
Nat Immunol. 2011 May;12(5):408-15. doi: 10.1038/ni.2022. Epub 2011 Apr 10.
2
Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome.载脂蛋白 E 缺陷型小鼠的动脉粥样硬化进展不依赖于 NLRP3 炎性小体。
Cell Death Dis. 2011 Mar 31;2(3):e137. doi: 10.1038/cddis.2011.18.
3
Monoclonal antibodies targeting IL-1 beta reduce biomarkers of atherosclerosis in vitro and inhibit atherosclerotic plaque formation in Apolipoprotein E-deficient mice.针对白细胞介素 1β的单克隆抗体可减少体外动脉粥样硬化生物标志物，并抑制载脂蛋白 E 缺陷小鼠的动脉粥样硬化斑块形成。
Atherosclerosis. 2011 Jun;216(2):313-20. doi: 10.1016/j.atherosclerosis.2011.02.026. Epub 2011 Feb 24.
4
The critical role of IL-1 receptor-associated kinase 4-mediated NF-κB activation in modified low-density lipoprotein-induced inflammatory gene expression and atherosclerosis.IL-1 受体相关激酶 4 介导的 NF-κB 激活在修饰型低密度脂蛋白诱导的炎症基因表达和动脉粥样硬化中的关键作用。
J Immunol. 2011 Mar 1;186(5):2871-80. doi: 10.4049/jimmunol.1002242. Epub 2011 Jan 28.
5
Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue.高血糖激活人脂肪组织中的 caspase-1 和 TXNIP 介导的 IL-1β转录。
Diabetes. 2011 Feb;60(2):517-24. doi: 10.2337/db10-0266.
6
Adipokines in inflammation and metabolic disease.脂肪细胞因子与炎症和代谢性疾病。
Nat Rev Immunol. 2011 Feb;11(2):85-97. doi: 10.1038/nri2921. Epub 2011 Jan 21.
7
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance.NLRP3 炎性体引发肥胖引起的炎症和胰岛素抵抗。
Nat Med. 2011 Feb;17(2):179-88. doi: 10.1038/nm.2279. Epub 2011 Jan 9.
8
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome.自噬蛋白通过抑制 NALP3 炎性小体介导的线粒体 DNA 的释放来调节先天免疫反应。
Nat Immunol. 2011 Mar;12(3):222-30. doi: 10.1038/ni.1980. Epub 2010 Dec 12.
9
A role for mitochondria in NLRP3 inflammasome activation.线粒体在 NLRP3 炎性小体激活中的作用。
Nature. 2011 Jan 13;469(7329):221-5. doi: 10.1038/nature09663. Epub 2010 Dec 1.
10
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity.炎症小体介导热激蛋白激活物酶-1 激活控制脂肪细胞分化和胰岛素敏感性。
Cell Metab. 2010 Dec 1;12(6):593-605. doi: 10.1016/j.cmet.2010.11.011.
Zotero 插件