Loh H H, Tseng L F, Wei E, Li C H
Proc Natl Acad Sci U S A. 1976 Aug;73(8):2895-8. doi: 10.1073/pnas.73.8.2895.
beta-Endorphin, an opiate-like peptide, has potent antinociceptive properties when it is administered directly into the brain and assayed in the the tail-flick, hot-plate, and writhing tests in mice and in the wet shake test in rats. On a molar basis, beta-endorphin is 18 to 33 times more potent than morphine and its actions are blocked by the specific opiate antagonist, naloxone hydrochloride. The activity of beta-endorphin in vivo is also compared to other peptides that show opiate-like activity in assays in vitro.
β-内啡肽是一种类阿片肽，当直接注入脑内并在小鼠的甩尾试验、热板试验、扭体试验以及大鼠的湿摇试验中进行测定时，它具有强大的抗伤害感受特性。以摩尔为基础计算，β-内啡肽的效力比吗啡强18至33倍，其作用可被特异性阿片拮抗剂盐酸纳洛酮阻断。β-内啡肽在体内的活性也与其他在体外试验中表现出类阿片活性的肽进行了比较。
