源自β-促脂素的一种肽β-促脂素-（61-91）的阿片样活性。
Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin.
作者信息
Cox B M, Goldstein A, Hi C H
出版信息
Proc Natl Acad Sci U S A. 1976 Jun;73(6):1821-3. doi: 10.1073/pnas.73.6.1821.
Abstract
The pituitary peptide beta-lipotropin displays essentially no opoid activity in a preparation of guinea pig ileum or in the opiate receptor binding assay. However, a fragment, beta-lipotropin-(61-91), with the enkephalin sequence (Tyr-Gly-Gly-Phe-Met) at its NH2-terminus, has typical opioid effects in these two assays.
摘要
垂体肽β-促脂素在豚鼠回肠制剂或阿片受体结合试验中基本没有阿片样活性。然而，一个片段β-促脂素-（61-91），在其NH2末端具有脑啡肽序列（酪氨酸-甘氨酸-甘氨酸-苯丙氨酸-甲硫氨酸），在这两种试验中具有典型的阿片样作用。
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