Binder J R, Swanson S J, Hammeke T A, Morris G L, Mueller W M, Fischer M, Benbadis S, Frost J A, Rao S M, Haughton V M
Department of Neurology, Medical College of Wisconsin, Milwaukee 53226, USA.
Neurology. 1996 Apr;46(4):978-84. doi: 10.1212/wnl.46.4.978.
We performed functional MRI (FMRI) in 22 consecutive epilepsy patients undergoing intracarotid amobarbital (Wada) testing and compared language lateralization measures obtained with the two procedures. FMRI used a single-word semantic decision task previously shown to activate lateralized language areas in normal adults. Correlation between the two tests was highly significant (r = 0.96; 95% CIs 0.90 to 0.98; p < 0.0001). These results validate the FMRI technique and suggest that "active" areas observed with this semantic processing task correspond to those underlying hemispheric dominance for language. This strong correlation observed supports the view that language lateralization is a continuous rather than a dichotomous variable. In addition to lateralization information, FMRI consistently demonstrated focal regions of activity in lateral frontal and temporo-parieto-occipital cortex. These functional maps may be helpful in defining the boundaries of surgical excisions.
我们对22例连续接受颈内动脉异戊巴比妥（Wada）试验的癫痫患者进行了功能磁共振成像（fMRI），并比较了两种检查所获得的语言侧化测量结果。fMRI采用了一个单词语义判断任务，该任务先前已被证明可激活正常成年人的侧化语言区域。两种测试之间的相关性非常显著（r = 0.96；95%可信区间为0.90至0.98；p < 0.0001）。这些结果验证了fMRI技术，并表明通过这种语义处理任务观察到的“活跃”区域与语言半球优势的潜在区域相对应。观察到的这种强相关性支持了语言侧化是一个连续而非二分变量的观点。除了侧化信息外，fMRI始终显示出额叶外侧和颞顶枕叶皮质的局灶性活动区域。这些功能图谱可能有助于确定手术切除的边界。
