Smith A G, Wald J
Department of Neurology, University of Michigan Medical Center, Ann Arbor 48109, USA.
Neurology. 1996 Apr;46(4):1143-5. doi: 10.1212/wnl.46.4.1143.
Respiratory failure is a common manifestation of myasthenia gravis but is infrequent in Lambert-Eaton myasthenic syndrome (LEMS), where it is often related to the use of paralytic agents or intercurrent pulmonary pathology. Therapies that are effective acutely in myasthenia gravis are usually of minimal benefit in LEMS. We describe a patient with respiratory failure secondary to LEMS who responded to 3,4-diaminopyridine and review the 12 previously reported cases of ventilatory failure in LEMS.
呼吸衰竭是重症肌无力的常见表现，但在兰伯特-伊顿肌无力综合征（LEMS）中并不常见，在LEMS中，呼吸衰竭常与使用麻痹剂或并发肺部病变有关。对重症肌无力急性有效的治疗方法对LEMS通常益处不大。我们描述了一名继发于LEMS的呼吸衰竭患者，该患者对3,4-二氨基吡啶有反应，并回顾了之前报道的12例LEMS通气衰竭病例。
