Leiter L A
Department of Medicine, University of Toronto, St Michael's Hospital, Ontario, Canada.
Am J Clin Nutr. 1996 Sep;64(3 Suppl):515S-518S. doi: 10.1093/ajcn/64.3.515S.
Weight gain is an important consequence of the intensive treatment of insulin-dependent diabetes mellitus (IDDM). Despite this, body composition in this disorder has not been well studied. Bioelectrical impedance analysis (BIA) has been shown to be a reliable, noninvasive method of assessing body composition but little is known about its use in IDDM. Therefore, a regression model estimating fat-free volume mass from bioelectrical impedance measurements obtained with proximal electrode placements was developed in 46 adults with IDDM through use of dual-energy X-ray absorptiometry (DXA) for reference values of fat-free mass. No effect of blood glucose concentration or prandial state on the impedance characteristics was observed. A regression model was developed incorporating the ratio of height squared to the minimum resistance of four limb-lead combinations (H2/R), total body weight, and a weight-sex interaction. With this model, BIA correlated closely with DXA (R2 = 0.982, residual SD = 1.3 kg). The applicability of these equations to non-insulin-dependent diabetes mellitus is unknown.
体重增加是胰岛素依赖型糖尿病（IDDM）强化治疗的一个重要后果。尽管如此，这种疾病的身体成分尚未得到充分研究。生物电阻抗分析（BIA）已被证明是一种可靠的、非侵入性的评估身体成分的方法，但对于其在IDDM中的应用知之甚少。因此，通过使用双能X线吸收法（DXA）获取无脂肪质量的参考值，在46名成年IDDM患者中建立了一个根据近端电极放置获得的生物电阻抗测量值估算无脂肪体积质量的回归模型。未观察到血糖浓度或用餐状态对阻抗特性有影响。建立了一个包含身高平方与四个肢体导联组合的最小电阻之比（H2/R）、总体重和体重-性别相互作用的回归模型。使用该模型，BIA与DXA密切相关（R2 = 0.982，残余标准差 = 1.3 kg）。这些方程对非胰岛素依赖型糖尿病的适用性尚不清楚。
