Leiter L A, Lukaski H C, Kenny D J, Barnie A, Camelon K, Ferguson R S, MacLean S, Simkins S, Zinman B, Cleary P A
Department of Medicine, University of Toronto, St Michael's Hospital, Ontario, Canada.
Int J Obes Relat Metab Disord. 1994 Dec;18(12):829-35.
Although weight gain often accompanies intensive treatment regimens designed to achieve near-normal glycemia in insulin-dependent diabetes mellitus (IDDM), body composition (BC) has not been well studied. Bioelectrical impedance analysis (BIA) is a safe, rapid, and non-invasive method of assessing BC but has not been utilized widely in IDDM. Data from 46 adults with IDDM were used to develop a regression model estimating fat-free body mass (FFM) from bioimpedance measurements obtained using a proximal electrode placement. Reference values of FFM were determined by dual x-ray absorptiometry (DXA). A model using the ratio of height squared to the minimum resistance of 4 limb-lead combinations (H2/R), total body weight, and a weight-gender interaction achieved a high level of accuracy (R2 = 0.982, residual standard deviation = 1.43 kg), while studies of 10 subjects before and after a light meal found no short-term effect of glycemia on measured BIA variables. BIA will therefore be used in combination with waist-to-hip ratios to study the composition and distribution of the increased weight associated with intensive therapy in the DCCT.
尽管在胰岛素依赖型糖尿病（IDDM）中，旨在实现血糖接近正常水平的强化治疗方案常常伴随着体重增加，但身体成分（BC）尚未得到充分研究。生物电阻抗分析（BIA）是一种安全、快速且无创的评估身体成分的方法，但在IDDM中尚未得到广泛应用。来自46名成年IDDM患者的数据被用于建立一个回归模型，该模型根据使用近端电极放置获得的生物阻抗测量值来估算去脂体重（FFM）。FFM的参考值通过双能X线吸收法（DXA）确定。一个使用身高平方与4种肢体导联组合的最小电阻之比（H2/R）、总体重以及体重-性别的相互作用的模型达到了较高的准确性（R2 = 0.982，残余标准差 = 1.43 kg），而对10名受试者在进食少量食物前后的研究发现，血糖对测量的BIA变量没有短期影响。因此，BIA将与腰臀比结合使用，以研究糖尿病控制与并发症试验（DCCT）中强化治疗相关体重增加的组成和分布情况。
