Matsuo T, Suzuki M
Division of Nutrition and Biochemistry, Sanyo Women's College, Hatsukaichi, Japan.
J Nutr Sci Vitaminol (Tokyo). 1996 Apr;42(2):133-43. doi: 10.3177/jnsv.42.133.
We examined the effects of dietary fats consisting of different fatty acids on alpha 2-adrenergic receptor binding in the hypothalamus and cerebral cortex. Sprague-Dawley male rats were meal-fed isoenergetic diets based on safflower oil or beef tallow for 8 weeks. alpha 2-Adrenergic receptor bindings were determined with [3H]para-aminoclonidine. Binding affinities of alpha 2-adrenergic receptor in the hypothalamus and cortex were significantly higher in the beef tallow diet group. The values of the polyunsaturated/saturated fatty acid ratio and the fluidity of the plasma membrane in the hypothalamus and cortex were lower in the beef tallow diet group than in the safflower oil diet group. These results suggest that the beef tallow diet decreases membrane fluidity by altering the fatty acid composition in rat brain regions. Consequently, alpha 2-adrenergic receptor binding affinities in the brain regions are higher in rats fed the beef tallow diet than in rats fed the safflower oil diet.
我们研究了由不同脂肪酸组成的膳食脂肪对下丘脑和大脑皮质中α2-肾上腺素能受体结合的影响。将雄性Sprague-Dawley大鼠以红花油或牛油为基础给予等能量的餐食喂养8周。用[3H]对氨基可乐定测定α2-肾上腺素能受体结合。牛油饮食组下丘脑和皮质中α2-肾上腺素能受体的结合亲和力显著更高。牛油饮食组下丘脑和皮质中多不饱和/饱和脂肪酸比值及质膜流动性的值低于红花油饮食组。这些结果表明，牛油饮食通过改变大鼠脑区的脂肪酸组成降低了膜流动性。因此，食用牛油饮食的大鼠脑区中α2-肾上腺素能受体结合亲和力高于食用红花油饮食的大鼠。
