Matsuo Tatsuhiro, Takeuchi Hiroyuki, Suzuki Hiroo, Suzuki Masashige
Faculty of Agriculture, Kagawa University, Kagawa, Japan.
Asia Pac J Clin Nutr. 2002;11(4):302-8. doi: 10.1046/j.1440-6047.2002.00299.x.
The effects of dietary fats , consisting of different fatty acids, on body fat accumulation and uncoupling protein (UCP) in interscapular brown adipose tissue were studied in rats. Metabolisable energy in experimental diets based on safflower oil, soybean oil or beef tallow was measured strictly (experiment 1). Male Wistar rats were then meal-fed an isoenergetic diet for 8 weeks (experiment 2). Each group of rats showed the same weight gain during the 8-week experimental period. Carcass fat content was greater in rats fed the beef tallow diet than in those fed the with the safflower or soybean oil diets, whereas the weight of abdominal adipose tissue was the same for all three dietary groups. Gene expression of UCP1 and the UCP content of the interscapular brown adipose tissue was lower in the beef tallow diet group than in the other dietary groups. A negative correlation was observed between carcass fat content and n-6 unsaturated fatty acid content in dietary fats. These results suggest that the greater body fat accumulation in rats fed the beef tallow diet results from lower expression of UCP1 mRNA and lower UCP content in brown adipose tissue. n-6 Polyunsaturated fatty acids may be the most effective fatty acids in limiting body fat.
研究了由不同脂肪酸组成的膳食脂肪对大鼠体脂积累及肩胛间棕色脂肪组织中解偶联蛋白（UCP）的影响。严格测定了以红花油、大豆油或牛脂为基础的实验日粮中的可代谢能量（实验1）。然后，雄性Wistar大鼠以等能量日粮分餐喂养8周（实验2）。在8周的实验期内，每组大鼠体重增加相同。饲喂牛脂日粮的大鼠胴体脂肪含量高于饲喂红花油或大豆油日粮的大鼠，而三个日粮组的腹部脂肪组织重量相同。牛脂日粮组肩胛间棕色脂肪组织中UCP1的基因表达和UCP含量低于其他日粮组。日粮脂肪中的胴体脂肪含量与n-6不饱和脂肪酸含量之间存在负相关。这些结果表明，饲喂牛脂日粮的大鼠体脂积累更多是由于棕色脂肪组织中UCP1 mRNA表达降低和UCP含量降低所致。n-6多不饱和脂肪酸可能是限制体脂最有效的脂肪酸。
