Toshima M, Kassell N F, Tanaka Y, Dougherty D A
Department of Neurological Surgery, University of Virginia Health Sciences Center, Charlottesville.
Acta Neurochir (Wien). 1992;119(1-4):134-8. doi: 10.1007/BF01541797.
We investigated the vasodilatory effect of intracisternal (i.c.) and intravenous (i.v.) administration of calcitonin gene-related peptide (CGRP) on arterial narrowing after experimental subarachnoid hemorrhage (SAH). Forty-one rabbits were divided into five groups: control (normal animals); SAH plus i.c. infusion of vehicle; SAH plus i.c. infusion of CGRP; SAH plus i.v. infusion of vehicle; SAH plus i.v. infusion of CGRP. In all but the control group, either CGRP (100 ng/kg/min) or vehicle solution was infused for two hours immediately prior to sacrifice by perfusion-fixation. A morphometric technique was employed to measure the luminal diameter of rabbit basilar arteries two days after SAH. The diameter of the basilar arteries in either the i.c. or i.v. CGRP groups was significantly greater than that of the respective vehicle group (i.c., p < 0.001; i.v., p < 0.01). Although there was no significant difference in systemic arterial blood pressure after infusion between the i.c. vehicle and i.c. CGRP groups, i.v. CGRP caused significant hypotension. Our results suggest that exogenous CGRP has some therapeutic potential for arterial narrowing after SAH not only by intrathecal application, but also by systemic use.
我们研究了脑池内（i.c.）和静脉内（i.v.）注射降钙素基因相关肽（CGRP）对实验性蛛网膜下腔出血（SAH）后动脉狭窄的血管舒张作用。41只兔子被分为五组：对照组（正常动物）；SAH加脑池内注射赋形剂；SAH加脑池内注射CGRP；SAH加静脉内注射赋形剂；SAH加静脉内注射CGRP。除对照组外，在通过灌注固定处死前两小时，均立即输注CGRP（100 ng/kg/min）或赋形剂溶液。采用形态计量学技术测量SAH后两天兔基底动脉的管腔直径。脑池内或静脉内注射CGRP组的基底动脉直径明显大于各自的赋形剂组（脑池内注射，p < 0.001；静脉内注射，p < 0.01）。虽然脑池内注射赋形剂组和脑池内注射CGRP组输注后全身动脉血压无显著差异，但静脉内注射CGRP导致明显低血压。我们的结果表明，外源性CGRP对SAH后动脉狭窄具有一定的治疗潜力，不仅可通过鞘内应用，也可通过全身应用。
