Henz B M, Jeep S, Ziegert F S, Niemann J, Kunkel G
Department of Dermatology and Asthma Poliklinik, Virchow Klinikum, Humboldt Universität zu Berlin, Germany.
Allergy. 1996 Mar;51(3):171-5. doi: 10.1111/j.1398-9995.1996.tb04582.x.
For investigation of a possible relationship between cutaneous and bronchial hyperreactivity, 74 subjects were grouped according to the presence (n = 33) or absence (n = 41) of urticarial dermographism after application of a standardized shearing pressure with a dermographometer (12.7 x 10(5) Pa). the two groups did not differ in age, sex, smoking habits, presence of urticaria and atopy, or serum IgE levels. Erythema of the dermographic test sites was always significantly greater (P < 0.001) in the group with urticarial dermographism at 2, 4, and 8 min, and cutaneous reactivity with titrated prick tests was significantly increased in this group with low concentrations of histamine, 0.01% and substance P (0.25 mM) (P < 0.05). After bronchial provocation with acetylcholine, 51 of the 74 subjects, 25 with and 26 without urticarial dermographism, exhibited bronchial hyperreactivity. However, significantly more subjects with urticarial dermographism had an increase in airway resistance and a decrease in specific airway conductance (P < 0.05). In the subgroup (n = 9) of subjects with symptomatic urticarial dermographism (urticaria factitia), these differences were even more significant (P < 0.001). These subjects also had larger skin test reactions and significantly higher IgE levels (P < 0.01). Thus, the present data show an association, which may be based on common mechanisms of allergic inflammation, between cutaneous and bronchial hyperreactivity.
为了研究皮肤和支气管高反应性之间可能存在的关系，74名受试者根据使用皮肤划纹计施加标准化剪切压力（12.7×10⁵帕）后是否出现风团性皮肤划痕症分为两组，有划痕症组（n = 33）和无划痕症组（n = 41）。两组在年龄、性别、吸烟习惯、是否患有荨麻疹和特应性疾病或血清IgE水平方面无差异。在有风团性皮肤划痕症的组中，皮肤划痕试验部位的红斑在2分钟、4分钟和8分钟时总是显著更明显（P < 0.001），并且该组在使用低浓度组胺（0.
