Barker G J, Tofts P S, Gass A
Institute of Neurology, London, UK.
Magn Reson Imaging. 1996;14(4):403-11. doi: 10.1016/0730-725x(96)00019-7.
We demonstrate an interleaved dual spin echo-based sequence for quantitative measurement of Magnetisation Transfer Ratio (MTR) in a clinical environment that overcomes the problems of patient motion between scans faced by noninterleaved methods. The sequence also provides proton density and T2-weighted images, allowing direct comparison among the three contrast regimes. Phantom studies and in vivo measurements on normal controls show the sequence to be robust in normal use. The values of MTR calculated from the sequence are shown to be precise and reproducible enough to allow regional variations to be identified within and between white matter and other brain tissues.
我们展示了一种基于交错双自旋回波的序列，用于在临床环境中定量测量磁化传递率（MTR），该序列克服了非交错方法在扫描之间面临的患者运动问题。该序列还提供质子密度和T2加权图像，允许在三种对比模式之间进行直接比较。对正常对照的体模研究和体内测量表明，该序列在正常使用中是稳健的。从该序列计算出的MTR值显示出足够精确和可重复，能够识别白质和其他脑组织内部及之间的区域差异。
