Hayashi Y, Ishihara N, Takahashi M, Fujii E, Uenakai K, Masada S, Ichimoto I
Research Laboratories II, Tamanoi Vinegar Co. Ltd., Osaka, Japan.
Biosci Biotechnol Biochem. 1996 Jul;60(7):1115-7. doi: 10.1271/bbb.60.1115.
A new cytotoxic compound 2 was isolated from a water extract of corn germ. Structural elucidation by spectroscopic data and chemical evidence fully substantiated 2 to be 11 (E)-10-oxo-11-octadecen-13-olide. Compound 2 exhibited considerably strong cytotoxic activity against various cell lines with IC50 of 0.9-2.8 micrograms/ml.
