补骨脂的细胞毒性成分。
Cytotoxic constituents of Psoralea corylifolia.
作者信息
Mar W, Je K H, Seo E K
机构信息
Natural Products Research Institute, Seoul National University, Korea.
出版信息
Arch Pharm Res. 2001 Jun;24(3):211-3. doi: 10.1007/BF02978259.
A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds of Psoralea corylifolia L. (Leguminosae) with the IC50 values of 0.3 and 0.4 microg/ml against the HT-29 (colon) and MCF-7 (breast) human cancer cell lines, respectively. A coumarin, angelicin (2) was also isolated as a marginally cytotoxic agent along with an inactive compound, psoralen (3) from the plant. The isolates 1-3 were not active against the A541 (lung) and HepG2 (liver hepatoma) cancer cell lines.
补骨脂素（1）是一种香豆雌酚衍生物，被发现是补骨脂（豆科）种子中的一种细胞毒性成分，对HT - 29（结肠）和MCF - 7（乳腺）人癌细胞系的IC50值分别为0.3和0.4微克/毫升。香豆素白芷素（2）也作为一种细胞毒性较弱的物质与植物中的一种无活性化合物补骨脂内酯（3）一起被分离出来。分离物1 - 3对A541（肺）和HepG2（肝癌）癌细胞系无活性。
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