Whitelaw A, Fawcett A R
Vet Rec. 1977 May 21;100(21):443-7. doi: 10.1136/vr.100.21.443.
In a farm-scale veterinary preventive programme run from 1973 to 1976 the use of rafoxanide (Flukanide; Merck Sharp & Dohme) in the prophylaxis of ovine fascioliasis resulted in a marked reduction in the percentage of ewes passing fluke eggs in the faeces and an absence of clinical cases of fascioliasis throughout these years. Three separate flocks of hill sheep were used in this study in which the aim of the dosing programme followed was to kill the majority of liver flukes (Fasciola hepatica) before they reached adult egg laying stage, thereby eliminating, or considerably reducing, the number of eggs passed on to the pasture.
在1973年至1976年开展的一项农场规模的兽医预防计划中，使用硝碘酚腈（氟氯苯腈；默克夏普&多贺美公司）预防绵羊肝片吸虫病，使得产粪中含有吸虫卵的母羊比例显著降低，并且在这些年里没有出现肝片吸虫病的临床病例。本研究使用了三个单独的山地绵羊群，所遵循的给药计划的目的是在大多数肝吸虫（肝片吸虫）达到成虫产卵阶段之前将其杀死，从而消除或大幅减少排到牧场的虫卵数量。
