Cringoli Giuseppe, Rinaldi Laura, Veneziano Vincenzo, Genchi Claudio
Dipartimento di Patologia e Sanità Animale, Università degli Studi di Napoli Federico II, CREMOPAR Regione Campania, Napoli, Italy.
Parasitol Res. 2006 Nov;99(6):700-5. doi: 10.1007/s00436-006-0223-y.
A clinical longitudinal field trial was conducted on a dairy sheep farm in southern Italy to assess the effectiveness of a novel anthelmintic treatment strategic scheme against Fasciola hepatica. The scheme utilizes a dual anthelmintic treatment (DAT), i.e., the use of either one of two different anthelmintics on the flock, albendazole sulphoxide (SO) at 1-month intervals and rafoxanide at 2-month intervals, administered to the lactating and non-lactating animals, respectively. The DAT strategic scheme lasted 3 years. In Year 1 and Year 2, shotgun monthly DATs for 5 consecutive months (July, August, September, October, and November) were performed on the flock. In Year 3 there was only one monthly DAT, in July. Overall, the DAT scheme reduced the prevalence of F. hepatica infection by 94.4% (from an average prevalence of 71.1% during the pre-DAT period to an average prevalence of 4.0% during Year 3), and the eggs/gram of faeces (EPG) from 29.3 to 1.3. In conclusion, the DAT strategic scheme reported in the present study successfully reduced both the prevalence and EPGs of F. hepatica to a level at which there were no longer any clinical symptoms of the disease. This scheme did not influence the albendazole SO efficacy against GI nematodes and might be used for the treatment of fasciolosis in dairy sheep farms.
在意大利南部的一个奶羊场进行了一项临床纵向现场试验，以评估一种新型抗蠕虫治疗策略方案对肝片吸虫的有效性。该方案采用双重抗蠕虫治疗（DAT），即在羊群中使用两种不同抗蠕虫药中的一种，分别对泌乳和非泌乳动物每隔1个月施用阿苯达唑亚砜（SO），每隔2个月施用雷复尼特。DAT策略方案持续了3年。在第1年和第2年，对羊群连续5个月（7月、8月、9月、10月和11月）每月进行一次突击DAT。在第3年，仅在7月进行了一次每月DAT。总体而言，DAT方案使肝片吸虫感染率降低了94.4%（从DAT前时期的平均感染率71.1%降至第3年的平均感染率4.0%），粪便虫卵计数（EPG）从29.3降至1.3。总之，本研究报告的DAT策略方案成功地将肝片吸虫的感染率和EPG降低到不再有任何该病临床症状的水平。该方案不影响阿苯达唑SO对胃肠道线虫的疗效，可用于奶羊场肝片吸虫病的治疗。
