Ph1阳性慢性髓性白血病联合化疗中的核型转化
Karyotypic conversion in Ph1-positive chronic myeloid leukaemia with combination chemotherapy.
作者信息
Sharp J C, Joyner M V, Wayne A W, Kemp J, Crofts M, Birch A D, McArthur G, Lai S, Sterndale H, Williams Y
出版信息
Lancet. 1979 Jun 30;1(8131):1370-2. doi: 10.1016/s0140-6736(79)92008-7.
PMID:87832
Abstract
Twelve previously untreated patients with Ph1-positive chronic myeloid leukaemia received combination chemotherapy soon after diagnosis. There was karyotypic conversion in five: in four, the percentage of Ph1-positive cells fell to 10 or less. In two other patients, who had mosaic karyotypes at presentation, the percentage fell to 5% and zero.
摘要
12名此前未经治疗的Ph1阳性慢性粒细胞白血病患者在确诊后不久接受了联合化疗。其中5名出现了核型转化：4名患者中，Ph1阳性细胞的百分比降至10%或更低。另外两名患者在初诊时为嵌合核型，其Ph1阳性细胞百分比分别降至5%和零。
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