肌醇单磷酸酶抑制剂、ATCC 20928因子A和C。分离、理化特性及生物学性质。

Inhibitors of myo-inositol monophosphatase, ATCC 20928 factors A and C. Isolation, physico-chemical characterization and biological properties.

作者信息

Stefanelli S, Sponga F, Ferrari P, Sottani C, Corti E, Brunati C, Islam K

机构信息

Lepetit Research Center, Marion-Merrell Dow Research Institute, Gerenzano (Va), Italy.

出版信息

J Antibiot (Tokyo). 1996 Jul;49(7):611-6. doi: 10.7164/antibiotics.49.611.

DOI:10.7164/antibiotics.49.611

PMID:8784418

Abstract

During the course of a screening program for inhibitors of myo-inositol monophosphatase we fermented the strain ATCC 20928, a known producer of L-671,776. We now show that this strain produces a complex of at least three sesquiterpenic compounds, L-671,776 (termed factor B) and two structurally related substances, termed factors A and C. Both factors A and C, like L-671,776, exhibited inhibitory activity against myo-inositol monophosphatase. Six other fungi producing the above mentioned compounds were also isolated and taxonomically characterized.

摘要

在一项针对肌醇单磷酸酶抑制剂的筛选计划中，我们培养了ATCC 20928菌株，它是已知的L-671,776的产生菌。我们现在表明，该菌株产生至少三种倍半萜类化合物的复合物，即L-671,776（称为因子B）以及两种结构相关的物质，称为因子A和因子C。因子A和因子C都像L-671,776一样，对肌醇单磷酸酶表现出抑制活性。还分离出了其他六种产生上述化合物的真菌，并对其进行了分类学鉴定。