Decoster A, Lecolier B
Laboratoire de Microbiologie, Hôpital St. Vincent, Lille, France.
J Clin Microbiol. 1996 Jul;34(7):1606-9. doi: 10.1128/JCM.34.7.1606-1609.1996.
The recent Access immunoanalysis system (Sanofi Diagnostics Pasteur) for the serological diagnosis of toxoplasmosis was compared with the Abbott Toxo IMx EIA system, taking the Platelia Toxo immunoglobulin G (IgG) and Platelia Toxo IgM systems as references and using as confirmation methods an indirect fluorescence assay or a dye test for IgG and an immunosorbent agglutination assay (ISAGA) for IgM. A total of 1,461 serum samples were studied, of which 128 were collected from 42 recently seroconverted patients. Sensitivity and specificity rates of the Access system were 97.7 and 99.5%, respectively, for IgM and 98.6 and 100%, respectively, for IgG. Sensitivity and specificity rates of the Abbott IMx EIA system were 91 and 100%, respectively, for IgM and 92.5 and 100%, respectively, for IgG. The Access Toxo IgG and IgM EIA systems were found to be more sensitive than the Abbott Toxo IgG and IgM IMx EIA systems.
将近期用于弓形虫病血清学诊断的Access免疫分析系统（赛诺菲巴斯德诊断公司）与雅培Toxo IMx酶免疫分析系统进行比较，以Platelia Toxo免疫球蛋白G（IgG）和Platelia Toxo IgM系统作为参照，并采用间接荧光试验或针对IgG的染色试验以及针对IgM的免疫吸附凝集试验（ISAGA）作为确证方法。共研究了1461份血清样本，其中128份取自42例近期血清学转换患者。Access系统针对IgM的灵敏度和特异度分别为97.7%和99.5%，针对IgG的灵敏度和特异度分别为98.6%和100%。雅培IMx酶免疫分析系统针对IgM的灵敏度和特异度分别为91%和100%，针对IgG的灵敏度和特异度分别为92.5%和100%。结果发现，Access弓形虫IgG和IgM酶免疫分析系统比雅培弓形虫IgG和IgM IMx酶免疫分析系统更灵敏。
