Stübgen J P
Department of Neurology, University of Pretoria, South Africa.
Electromyogr Clin Neurophysiol. 1995 Oct;35(6):351-7.
Quantitative electromyography (EMG) using different needle techniques has not been performed on a large limb girdle muscular dystrophy (LGMD) group.
To establish statistically: (1) correlations between clinical features (patient age, disease duration, degree of weakness) and quantitative needle EMG; (2) correlations between different needle EMG parameters, and (3) differences in quantitative EMG comparing patients with a healthy control group.
Nerve conduction studies and needle EMG (motorunit analysis, MacroEMG, SFEMG) were performed on Mm. triceps brachii and tibialis anterior according to standard techniques on 20 LGMD patients.
Nerve conduction studies were essentially normal. Motorunit analysis and MacroEMG parameters correlated with various clinical features. SFEMG results did not correlate with either clinical measures or other needle EMG findings. There was a significant difference between patients and controls in motorunit analysis and MacroEMG results.
(1) Progressive weakness correlated with concentric needle and MacroEMG indicators of progressive muscle fibre degeneration and loss. (2) SFEMG showed that muscle fibre reinnervation followed a course independent of fibre degeneration, and measured clinical features.
尚未对大型肢体带型肌营养不良症（LGMD）患者群体采用不同针电极技术进行定量肌电图（EMG）检查。
进行统计学分析以确定：（1）临床特征（患者年龄、病程、肌无力程度）与定量针电极EMG之间的相关性；（2）不同针电极EMG参数之间的相关性；以及（3）LGMD患者与健康对照组在定量EMG方面的差异。
按照标准技术，对20例LGMD患者的肱三头肌和胫前肌进行神经传导研究及针电极EMG检查（运动单位分析、巨肌电图、单纤维肌电图）。
神经传导研究基本正常。运动单位分析和巨肌电图参数与多种临床特征相关。单纤维肌电图结果与临床指标或其他针电极EMG检查结果均无相关性。患者与对照组在运动单位分析和巨肌电图结果方面存在显著差异。
（1）进行性肌无力与肌肉纤维进行性变性和丢失的同心针电极及巨肌电图指标相关。（2）单纤维肌电图显示，肌纤维再支配过程独立于纤维变性，且可测量临床特征。
