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Class I HLA is associated with age-at-onset of IDDM, while class II HLA confers susceptibility to IDDM.

作者信息

Fujisawa T, Ikegami H, Kawaguchi Y, Yamato E, Takekawa K, Nakagawa Y, Hamada Y, Ueda H, Shima K, Ogihara T

出版信息

Diabetologia. 1995 Dec;38(12):1493-5. doi: 10.1007/BF00400620.

DOI:10.1007/BF00400620
PMID:8786033
Abstract
摘要

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Class I HLA is associated with age-at-onset of IDDM, while class II HLA confers susceptibility to IDDM.I类人类白细胞抗原与胰岛素依赖型糖尿病的发病年龄相关，而II类人类白细胞抗原则赋予对胰岛素依赖型糖尿病的易感性。
Diabetologia. 1995 Dec;38(12):1493-5. doi: 10.1007/BF00400620.
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3
Genetic predisposition and IDDM in Greece.希腊的遗传易感性与胰岛素依赖型糖尿病
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HLA-DQ rather than HLA-DR region might be involved in dominant nonsusceptibility to diabetes.HLA-DQ区域而非HLA-DR区域可能与对糖尿病的显性不易感有关。
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Susceptibility and resistance alleles of human leukocyte antigen (HLA) DQA1 and HLA DQB1 are shared in endocrine autoimmune disease.人类白细胞抗原（HLA）DQA1和HLA DQB1的易感和抗性等位基因在内分泌自身免疫性疾病中是共享的。
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Circulating β cell-specific CD8 T cells restricted by high-risk HLA class I molecules show antigen experience in children with and at risk of type 1 diabetes.

本文引用的文献

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Is the high incidence of diabetes in young children diagnosed under the age of 4 years determined by genetic factors in Finland? The DIME Study Group.4岁以下幼儿中糖尿病的高发病率是由芬兰的遗传因素决定的吗？DIME研究小组。
Diabete Metab. 1993;19(1 Pt 2):167-72.
2
MHC-linked diabetogenic gene of the NOD mouse: molecular mapping of the 3' boundary of the diabetogenic region.非肥胖糖尿病（NOD）小鼠的主要组织相容性复合体（MHC）连锁致糖尿病基因：致糖尿病区域3'边界的分子定位
Biochem Biophys Res Commun. 1993 Apr 30;192(2):677-82. doi: 10.1006/bbrc.1993.1468.
3
Absence of association of TAP and LMP genes with type 1 (insulin-dependent) diabetes mellitus.
循环中β细胞特异性 CD8 T 细胞受高危 HLA I 类分子限制，在 1 型糖尿病患儿及其高危人群中表现出抗原经历。
Clin Exp Immunol. 2020 Mar;199(3):263-277. doi: 10.1111/cei.13391. Epub 2019 Nov 10.
4
DLA class II alleles and haplotypes are associated with risk for and protection from chronic hepatitis in the English Springer spaniel.DLA Ⅱ类等位基因和单倍型与英国史宾格犬慢性肝炎的风险和保护有关。
PLoS One. 2012;7(8):e42584. doi: 10.1371/journal.pone.0042584. Epub 2012 Aug 1.
5
The role of HLA class I gene variation in autoimmune diabetes.HLA I类基因变异在自身免疫性糖尿病中的作用。
Rev Diabet Stud. 2005 Summer;2(2):97-109. doi: 10.1900/RDS.2005.2.97. Epub 2005 Aug 10.
6
Human leukocyte antigen class I B and C loci contribute to Type 1 Diabetes (T1D) susceptibility and age at T1D onset.人类白细胞抗原I类B和C基因座与1型糖尿病（T1D）易感性及T1D发病年龄有关。
Hum Immunol. 2005 Mar;66(3):301-13. doi: 10.1016/j.humimm.2004.12.001.
7
Allelic variation in class I K gene as candidate for a second component of MHC-linked susceptibility to type 1 diabetes in non-obese diabetic mice.I类K基因中的等位基因变异作为非肥胖糖尿病小鼠中MHC连锁的1型糖尿病易感性第二个组成部分的候选因素。
Diabetologia. 2004 Apr;47(4):739-47. doi: 10.1007/s00125-004-1370-2.
8
The HLA class I A locus affects susceptibility to type 1 diabetes.人类白细胞抗原I类A基因座影响1型糖尿病的易感性。
Hum Immunol. 2002 Aug;63(8):657-64. doi: 10.1016/s0198-8859(02)00421-4.
9
Genetic predisposition to IDDM.胰岛素依赖型糖尿病的遗传易感性。
Clin Rev Allergy Immunol. 2000 Dec;19(3):227-46. doi: 10.1385/CRIAI:19:3:227.
10
The predisposition to type 1 diabetes linked to the human leukocyte antigen complex includes at least one non-class II gene.与人类白细胞抗原复合体相关的1型糖尿病易感性至少包括一个非II类基因。
Am J Hum Genet. 1999 Mar;64(3):793-800. doi: 10.1086/302283.
Life Sci. 1994;54(26):2049-53. doi: 10.1016/0024-3205(94)00713-6.
4
Polymorphism of HSP70 gene is not associated with type 1 (insulin-dependent) diabetes mellitus in Japanese.
Diabetes Res Clin Pract. 1993 Aug-Sep;21(2-3):103-7. doi: 10.1016/0168-8227(93)90056-b.
5
A new marker in the HLA class I region is associated with the age at onset of IDDM.HLA I类区域中的一个新标记物与胰岛素依赖型糖尿病的发病年龄相关。
Diabetologia. 1995 May;38(5):623-8. doi: 10.1007/BF00400734.
6
Age-related association of insulin-dependent diabetes mellitus with BfF1 and the HLA-B18, BfF1 haplotype.胰岛素依赖型糖尿病与BfF1以及HLA - B18、BfF1单倍型的年龄相关性关联。
Diabetologia. 1981 Jul;21(1):47-9. doi: 10.1007/BF03216223.
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Rapid detection of IDDM susceptibility with HLA-DQ beta-alleles as markers.以HLA-DQβ等位基因为标记快速检测胰岛素依赖型糖尿病易感性。
Diabetes. 1989 Dec;38(12):1617-22. doi: 10.2337/diab.38.12.1617.
8
Linkage of faulty major histocompatibility complex class I to autoimmune diabetes.
Science. 1991 Dec 20;254(5039):1756-61. doi: 10.1126/science.1763324.
9
Age-dependent HLA genetic heterogeneity of type 1 insulin-dependent diabetes mellitus.1型胰岛素依赖型糖尿病的年龄依赖性HLA基因异质性。
J Clin Invest. 1992 Dec;90(6):2242-50. doi: 10.1172/JCI116110.
10
Prevention of autoimmune insulitis in nonobese diabetic mice by expression of major histocompatibility complex class I Ld molecules.通过表达主要组织相容性复合体I类Ld分子预防非肥胖糖尿病小鼠的自身免疫性胰岛炎。
Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9519-23. doi: 10.1073/pnas.89.20.9519.