将四个基因、一个假基因、31个序列标签位点（STSs）和一个高度多态的短串联重复序列（STRP）整合到5q34 - q35的7 - 10兆碱基酵母人工染色体（YAC）重叠群中。

Integration of four genes, a pseudogene, thirty-one STSs, and a highly polymorphic STRP into the 7-10 Mb YAC contig of 5q34-q35.

作者信息

Kostrzewa M, Grady D L, Moyzis R K, Flöter L, Müller U

机构信息

Institut für Humangenetik, Justus-Liebig-Universität, Giessen, Germany.

出版信息

Hum Genet. 1996 Mar;97(3):399-403. doi: 10.1007/BF02185781.

DOI:10.1007/BF02185781

PMID:8786091

Abstract

Thirty-one sequence tagged sites and a highly polymorphic short tandem repeat polymorphism have been isolated from 5q34-q35 and integrated into the yeast artificial chromosome (YAC) contig of 5q34-q35. In addition, four genes (MSX2, CSX, DRD1, and CL100) and a pseudogene (GLUT6) were localized on this map. The high density of new markers in the region allowed further refinement of the YAC contig of distal 5q. This is a prerequisite for the conversion of this YAC into a cosmid contig.

摘要

从5q34 - q35分离出31个序列标签位点和一个高度多态的短串联重复多态性，并将其整合到5q34 - q35的酵母人工染色体（YAC）重叠群中。此外，四个基因（MSX2、CSX、DRD1和CL100）和一个假基因（GLUT6）定位在该图谱上。该区域新标记的高密度使得5q远端的YAC重叠群得以进一步优化。这是将该YAC转化为黏粒重叠群的先决条件。