Jarvis B B, Zhou Y, Jiang J, Wang S, Sorenson W G, Hintikka E L, Nikulin M, Parikka P, Etzel R A, Dearborn D G
Department of Chemistry and Biochemistry, University of Maryland, College Park 20742, USA.
J Nat Prod. 1996 Jun;59(6):553-4. doi: 10.1021/np960395t.
An investigation of a cluster of cases of pulmonary hemosiderosis in infants in Cleveland, OH, led to the isolation of many isolates of Stachybotrys atra and two isolates of a related toxigenic fungus, Memnoniella echinata. M. echinata produces two cytotoxic trichothecene mycotoxins, trichodermol (1a) and trichodermin (1b), as well as several griseofulvins. Dechlorogriseofulvin (2a) and epidechlorogriseofulvin (2b) were the major compounds isolated. This is the first report of a fungus outside the Penicillium genus producing griseofulvins.
对俄亥俄州克利夫兰市一群婴儿肺含铁血黄素沉着症病例的调查，导致分离出许多黑葡萄穗霉菌株以及两种相关产毒真菌——刺孢小克银汉霉菌株。刺孢小克银汉霉产生两种细胞毒性单端孢霉烯族霉菌毒素，即木霉醇（1a）和木霉菌素（1b），以及几种灰黄霉素。脱氯灰黄霉素（2a）和表脱氯灰黄霉素（2b）是分离出的主要化合物。这是首次关于青霉属以外的真菌产生灰黄霉素的报道。
