Bieber T
Clinique et Policlinique Dermatologique, Université Ludwig-Maximilian, MUNICH, Allemagne.
Pathol Biol (Paris). 1995 Dec;43(10):871-5.
The demonstration of IgE receptors on the surface of epidermal dendritic cells and on other antigen presenting cells is a crucial element in the understanding of the pathophysiological role of these cells in the genesis of atopic disease, and especially the atopic dermatitis (AD). The sensibilisation phase to an aeroallergen at the level of nasal or bronchial mucosa and even at the skin may be mediated by dendritic cells expressing Fc epsilon RI. Distinct forms of AD may then represent the equivalent of the ellicitation phase of the classical allergic contact dermatitis. Fc epsilon RI would lead, via specific IgE, to an efficient antigen capture, to the activation of the dendritic cells and finally to an antigen presentation. Thus, AD may represent the paradigma of an IgE-mediated type IV reaction.
表皮树突状细胞表面及其他抗原呈递细胞上IgE受体的证实，是理解这些细胞在特应性疾病尤其是特应性皮炎（AD）发生发展中病理生理作用的关键因素。在鼻或支气管黏膜甚至皮肤水平对气传变应原的致敏阶段，可能由表达FcεRI的树突状细胞介导。不同形式的AD可能相当于经典过敏性接触性皮炎的激发阶段。FcεRI会通过特异性IgE导致有效的抗原捕获、树突状细胞的激活，最终实现抗原呈递。因此，AD可能代表IgE介导的IV型反应的范例。
