氟哌啶醇对衰老过程中大鼠垂体、下丘脑和纹状体中甲硫氨酸脑啡肽、β-内啡肽、胆囊收缩素和P物质的影响。

The effect of haloperidol on met-enkephalin, beta-endorphin, cholecystokinin and substance P in the pituitary, the hypothalamus and the striatum of rats during aging.

Lau S M, Tang F

Department of Physiology, University of Hong Kong.

Prog Neuropsychopharmacol Biol Psychiatry. 1995 Nov;19(7):1163-75. doi: 10.1016/0278-5846(95)00234-0.

Abstract

Haloperidol increased the Met-enk level in the striatum at all age groups. However, the Met-enk level was decreased in AL of young and middle-aged rats by the drug. 2. Haloperidol elevated the beta-end level in AL and CCK level in NIL in young rats only. 3. The SP content in NIL was decreased by haloperidol in all age groups. 4. With regard to the effect of aging, Met-enk level in AL of middle-aged rats was higher than that in young rats. The beta-end level in AL also increased in old rats. 5. Aging modified the haloperidol effect on beta-end level in AL and CCK level in NIL as the effect was only observed in young rats. 6. In addition, aging caused a blunted response of Met-enk level to haloperidol in the striatum but an increased response of SP content to haloperidol in the NIL.

摘要

氟哌啶醇在所有年龄组中均增加了纹状体中甲硫氨酸脑啡肽（Met-enk）水平。然而，该药物使年轻和中年大鼠杏仁核（AL）中的Met-enk水平降低。2. 氟哌啶醇仅在年轻大鼠中提高了杏仁核中的β-内啡肽（beta-end）水平以及伏隔核（NIL）中的胆囊收缩素（CCK）水平。3. 氟哌啶醇在所有年龄组中均降低了伏隔核中的速激肽（SP）含量。4. 关于衰老的影响，中年大鼠杏仁核中的Met-enk水平高于年轻大鼠。老年大鼠杏仁核中的β-内啡肽水平也有所增加。5. 衰老改变了氟哌啶醇对杏仁核中β-内啡肽水平和伏隔核中CCK水平的影响，因为这种影响仅在年轻大鼠中观察到。6. 此外，衰老导致纹状体中Met-enk水平对氟哌啶醇的反应减弱，但伏隔核中SP含量对氟哌啶醇的反应增强。