Silver R, Silverman A J, Vitković L, Lederhendler I I
Psychology Dept, Barnard College and Columbia University, New York, NY, USA.
Trends Neurosci. 1996 Jan;19(1):25-31. doi: 10.1016/0166-2236(96)81863-7.
For the past two decades the brain has been considered to be an immune-privileged site that excludes circulating cells from the parenchyma. New evidence indicates that some hematocytes reside in the brain, while others traffic through it. Mast cells belong to both of these functional types. Moreover, the appearance of mast cells in the CNS can be triggered behaviorally. After a brief period of courtship, for example, there is a marked increase in mast cells in the medial habenula of sexually active doves compared with controls. Exposure to gonadal steroids that occur endogenously or that are administered exogenously increases both the number of mast cells and their state of activation in the brain. These results show that hematopoietic cells can provide targeted delivery of neuromodulators to specific regions of the brain, thereby influencing neural-endocrine interactions.
在过去二十年中，大脑一直被认为是一个免疫特权部位，可将循环细胞排除在实质之外。新证据表明，一些血细胞存在于大脑中，而另一些则穿过大脑。肥大细胞属于这两种功能类型。此外，中枢神经系统中肥大细胞的出现可由行为触发。例如，经过短暂的求偶期后，与对照组相比，性活跃鸽子内侧缰核中的肥大细胞显著增加。内源性或外源性给予性腺类固醇会增加大脑中肥大细胞的数量及其激活状态。这些结果表明，造血细胞可以将神经调节剂靶向递送至大脑的特定区域，从而影响神经内分泌相互作用。
