Johnson D, Krenger W
Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115.
Neurochem Res. 1992 Sep;17(9):939-51. doi: 10.1007/BF00993271.
This article reviews recent advances in the understanding of mast cell-nervous system interactions. It is drawn largely from work published within the last ten years, and discusses the anatomical and biochemical evidence of a functional connection between mast cells and the nervous system, and the implications that such a relationship may have for normal and abnormal physiological functioning. Mast cells are found at varying levels of association with the nervous system; in CNS parenchyma (mainly thalamus), in connective tissue coverings (e.g. meninges, endoneurium), and in close apposition to peripheral nerve endings in a variety of tissues. There is, as yet, no clearly defined role for mast cells in nervous system function, or vice-versa, and it seems most likely that their interactions fulfil mutually modulatory roles. By extension, pathological situations where one of the partners in this relationship is overly stimulated may lead to a dysregulation of the other, and contribute to disease symptomatology.
本文综述了对肥大细胞与神经系统相互作用理解的最新进展。内容主要取材于过去十年内发表的研究成果，探讨了肥大细胞与神经系统之间功能联系的解剖学和生物化学证据，以及这种关系对正常和异常生理功能可能产生的影响。肥大细胞与神经系统的关联程度各不相同；存在于中枢神经系统实质（主要是丘脑）、结缔组织被膜（如脑膜、神经内膜）中，并且在多种组织中与外周神经末梢紧密相邻。目前，肥大细胞在神经系统功能中尚无明确界定的作用，反之亦然，它们之间的相互作用似乎最有可能发挥相互调节的作用。由此推断，这种关系中一方过度受刺激的病理情况可能导致另一方的调节失衡，并促成疾病症状的出现。
