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一种用于测定动物组织中类金属硫蛋白的改良方法。

A modified procedure for determination of metallothionein-like proteins in animal tissues.

作者信息

Zelazowski A J, Piotrowski J K

出版信息

Acta Biochim Pol. 1977;24(2):97-103.

PMID:878738
Abstract
  1. The effect of low-molecular-weight substances interfering with determination of metallothionein is eliminated by precipitation of 203Hg-thionein by tannic acid. 2. In animals not exposed to metals, the mean values for metallothionein content in liver and kidney are, respectively, 0.10 and 0.18 mg/g in rats, 0.06 and 0.07 in mice and 0.12 and 0.29 in guinea-pigs, i.e. are 2-3 times lower as compared with the values obtained by the procedure not involving treatment with tannic acid.
摘要
  1. 低分子量物质干扰金属硫蛋白测定的影响可通过用单宁酸沉淀203Hg-硫蛋白来消除。2. 在未接触金属的动物中，大鼠肝脏和肾脏中金属硫蛋白含量的平均值分别为0.10和0.18毫克/克，小鼠为0.06和0.07，豚鼠为0.12和0.29，即与未用单宁酸处理的方法所获得的值相比低2至3倍。

相似文献

1
A modified procedure for determination of metallothionein-like proteins in animal tissues.一种用于测定动物组织中类金属硫蛋白的改良方法。
Acta Biochim Pol. 1977;24(2):97-103.
2
The levels of metallothionein-like proteins in animal tissues.
Experientia. 1977 Dec 15;33(12):1624-5. doi: 10.1007/BF01934037.
3
Evaluation of metallothionein content in animal tissues.动物组织中金属硫蛋白含量的评估。
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Content of mercury in chromatin and level of metallothionein proteins in kidneys and liver of rats.大鼠染色质中的汞含量以及肾脏和肝脏中金属硫蛋白的水平。
Biochem Pharmacol. 1981 Aug 1;30(15):2177-8. doi: 10.1016/0006-2952(81)90242-2.
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Low-molecular weight metalloproteins in tissues of the narwhal (Monodon monoceros).
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Comparison of methods for estimating hepatic metallothionein in rats.大鼠肝脏金属硫蛋白估算方法的比较
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The effects of chronic cobalt exposure on behavior and metallothionein levels in the adult rat.慢性钴暴露对成年大鼠行为及金属硫蛋白水平的影响。
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Development of a radioimmunoassay for rat liver metallothionein-I and its application to the analysis of rat plasma and kidneys.大鼠肝脏金属硫蛋白-I放射免疫测定法的建立及其在大鼠血浆和肾脏分析中的应用。
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Arch Environ Contam Toxicol. 1979;8(3):255-68. doi: 10.1007/BF01056242.
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Metallothionein and the subcellular localization of mercury and cadmium in the California sea lion.
Comp Biochem Physiol C Comp Pharmacol. 1977;57(1):45-53. doi: 10.1016/0306-4492(77)90076-4.

引用本文的文献

1
Low molecular weight cadmium-and copper-binding proteins from rat kidneys.大鼠肾脏中小分子巯基镉和铜结合蛋白。
Biol Trace Elem Res. 1980 Jun;2(2):137-48. doi: 10.1007/BF02798592.
2
Variation of the level of mercury and metallothionein in the kidneys and liver of rats with time of exposure to sodium selenite.随着暴露于亚硒酸钠时间的变化，大鼠肾脏和肝脏中的汞和金属硫蛋白水平的变化。
Biol Trace Elem Res. 1980 Jun;2(2):109-20. doi: 10.1007/BF02798590.
3
Cadmium, zinc, copper, and metallothionein levels in the kidney and liver of inhabitants of upper Silesia (Poland).
波兰上西里西亚地区居民肾脏和肝脏中的镉、锌、铜及金属硫蛋白水平
Int Arch Occup Environ Health. 1993;65(1):57-63. doi: 10.1007/BF00586060.
4
Effects of cadmium and zinc on tissue levels of metallothionein.镉和锌对金属硫蛋白组织水平的影响。
Environ Health Perspect. 1984 Mar;54:67-72. doi: 10.1289/ehp.845467.
5
Development of a radioimmunoassay for rat liver metallothionein-I and its application to the analysis of rat plasma and kidneys.大鼠肝脏金属硫蛋白-I放射免疫测定法的建立及其在大鼠血浆和肾脏分析中的应用。
Biochem J. 1983 Aug 1;213(2):459-65. doi: 10.1042/bj2130459.
6
Metallothionein--aspects related to copper and zinc metabolism.金属硫蛋白——与铜和锌代谢相关的方面。
J Inherit Metab Dis. 1983;6 Suppl 1:15-21. doi: 10.1007/BF01811318.
7
Effect of interaction between 65Zn, mercury and selenium in rats (retention, metallothionein, endogenous copper).65锌、汞和硒之间的相互作用对大鼠的影响（潴留、金属硫蛋白、内源性铜）
Arch Toxicol. 1983 Jun;53(2):165-75. doi: 10.1007/BF00302724.
8
Effect of oral cadmium administration to female rats during pregnancy on zinc, copper, and iron content in placenta, foetal liver, kidney, intestine, and brain.孕期口服镉对雌性大鼠胎盘、胎儿肝脏、肾脏、肠道和大脑中锌、铜和铁含量的影响。
Arch Toxicol. 1985 Feb;56(4):256-62. doi: 10.1007/BF00295164.
9
Interaction of alkylmercuric compounds with sodium selenite. III. Biotransformation, levels of metallothioneinlike proteins and endogenous copper in some tissues of rats exposed to methyl or ethylmercuric chloride with and without sodium selenite.烷基汞化合物与亚硒酸钠的相互作用。III. 暴露于氯化甲基汞或氯化乙基汞（添加或不添加亚硒酸钠）的大鼠某些组织中的生物转化、类金属硫蛋白水平和内源性铜含量
Environ Health Perspect. 1985 May;60:423-31. doi: 10.1289/ehp.60-1568568.
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Kidney concentrations and urinary excretion of mercury, zinc and copper following the administration of mercuric chloride and sodium selenite to rats.给大鼠注射氯化汞和亚硒酸钠后，其肾脏中汞、锌和铜的含量及尿排泄情况。
Arch Toxicol. 1986 May;59(1):16-20. doi: 10.1007/BF00263951.