样本数量和活检部位对弥漫性肺疾病组织学诊断的影响。
Influence of sample number and biopsy site on the histologic diagnosis of diffuse lung disease.
作者信息
Flint A, Martinez F J, Young M L, Whyte R I, Toews G B, Lynch J P
机构信息
Department of Pathology, University of Michigan, Ann Arbor, USA.
出版信息
Ann Thorac Surg. 1995 Dec;60(6):1605-7; discussion 1607-8. doi: 10.1016/0003-4975(95)00895-0.
BACKGROUND
Although open biopsy is considered the optimal method for obtaining lung tissue for the diagnosis of diffuse infiltrative pulmonary disorders, there are no universally established guidelines concerning biopsy site selection and the ideal number of tissue samples. Relatively few investigations have been devoted to the influence exerted by the site and number of biopsy samples on the histologic diagnosis.
METHODS
Seventy-seven open biopsy samples obtained from different lobes of 28 patients with idiopathic pulmonary fibrosis were analyzed. The histopathologic features were evaluated semiquantitatively and the results from each sample compared with those of the other samples obtained from each patient.
RESULTS
Statistically significant differences in histopathologic features were not observed between samples.
CONCLUSIONS
A single generous (2 cm or greater diameter) sample, obtained from a representative region of the radiographically most involved lobe, will suffice for diagnostic and evaluation purposes.
背景
尽管开放活检被认为是获取肺组织以诊断弥漫性浸润性肺部疾病的最佳方法，但关于活检部位选择和理想的组织样本数量，尚无普遍确立的指南。相对较少的研究致力于活检样本的部位和数量对组织学诊断的影响。
方法
对28例特发性肺纤维化患者不同肺叶获取的77份开放活检样本进行分析。对组织病理学特征进行半定量评估，并将每个样本的结果与从每位患者获取的其他样本的结果进行比较。
结果
样本之间未观察到组织病理学特征的统计学显著差异。
结论
从影像学上受累最严重肺叶的代表性区域获取一个足够大（直径2厘米或更大）的样本，就足以用于诊断和评估目的。
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